| expression profiling of lymph node cells from deer mice infected with andes virus. | deer mice (peromyscus maniculatus) are the principal reservoir hosts of sin nombre virus (snv), the cause of the great majority of hantavirus cardiopulmonary syndrome (hcps) cases in north america. snv, like all hantaviruses with their reservoirs, causes persistent infection without pathology in deer mice and appear to elicit a regulatory t cell response. deer mice are also susceptible to andes virus (andv), which causes the great majority of hcps cases in south america, but they clear infection ... | 2013 | 23570545 |
| transcriptome markers of viral persistence in naturally-infected andes virus (bunyaviridae) seropositive long-tailed pygmy rice rats. | long-tailed pygmy rice rats (oligoryzomys longicaudatus) are principal reservoir hosts of andes virus (andv) (bunyaviridae), which causes most hantavirus cardiopulmonary syndrome cases in the americas. to develop tools for the study of the andv-host interactions, we used rna-seq to generate a de novo transcriptome assembly. splenic rna from five rice rats captured in chile, three of which were andv-infected, was used to generate an assembly of 66,173 annotated transcripts, including noncoding rn ... | 2015 | 25856432 |
| differential lymphocyte and antibody responses in deer mice infected with sin nombre hantavirus or andes hantavirus. | hantavirus cardiopulmonary syndrome (hcps) is a rodent-borne disease with a high case-fatality rate that is caused by several new world hantaviruses. each pathogenic hantavirus is naturally hosted by a principal rodent species without conspicuous disease and infection is persistent, perhaps for life. deer mice (peromyscus maniculatus) are the natural reservoirs of sin nombre virus (snv), the etiologic agent of most hcps cases in north america. deer mice remain infected despite a helper t cell re ... | 2014 | 24829335 |
| rapid enzyme-linked immunosorbent assay for the detection of hantavirus-specific antibodies in divergent small mammals. | we assessed the utility of an enzyme-linked immunosorbent assay (elisa) for the detection of hantavirus-specific antibodies from sera of oligoryzomys longicaudatus, the principal reservoir of andes virus (andv), using an antigen previously developed for detection of antibodies to sin nombre virus (snv) in sera from peromyscus maniculatus. the assay uses a protein a/g horseradish peroxidase conjugate and can be performed in as little as 1.5 hours. serum samples from oligoryzomys longicaudatus col ... | 2014 | 24806874 |