endocarditis caused by blastoschizomyces capitatus and taxonomic review of the genus.blastoschizomyces capitatus salkin, gordon, samsonoff et rieder was found to be the etiologic agent of endocarditis in a patient with a prosthetic mitral valve. cultures inoculated with peripheral blood and portions of the valve yielded b. capitatus. examination of stained tissue sections revealed the presence of fungal filaments morphologically consistent with this organism. the salient characteristics of b. capitatus and the factors contributing to its recognition as a distinct taxon are descr ...19921400996
fluconazole treatment of blastoschizomyces capitatus meningitis in an allogeneic bone marrow recipient.the first known case of blastoschizomyces capitatus meningitis occurring in an allogeneic bone marrow recipient on steroid and cyclosporine therapy for chronic graft-versus-host disease is reported. an 11-month course of treatment with oral fluconazole resulted in resolution of the meningeal syndrome and eradication of blastoschizomyces capitatus from the cerebrospinal fluid. three months after discontinuation of fluconazole the patient died due to idiopathic interstitial pneumonia and bilateral ...19911810730
[trichosporon capitatum septicemia in immunosuppressed patients].disseminated trichosporon capitatum infections are seldom reported. we observed 3 cases in leukemic patients within 4 months. all 3 patients were granulocytopenic. one of them was also treated with cyclosporine and methyl-prednisolone after an allogenic bone marrow transplant. the portal of entry was certainly the digestive tract as tr. capitatum have been isolated in the stool before the septicemia. all 3 patients were previously treated with an azole antifungal compound. the part of this treat ...19902385456
immunoblot analysis of the serological response in invasive trichosporon beigelii and blastoschizomyces capitatus infections.the serological response to trichosporon sp. was examined by the immunoblot technique. antibodies to a range of antigens (200 to 16 kilodaltons) were detectable in three patients with invasive trichosporon beigelii or blastoschizomyces capitatus infections and 10 uninfected controls. high levels of preexisting antibodies may contribute to the rarity of systemic infections.19863517056
systemic infection with trichosporon capitatum in two patients with acute leukaemia.trichosporon capitatum was isolated from the blood of two patients with acute leukaemia who were undergoing induction chemotherapy. both patients died of their infections, and the fungus was cultured from their tissues after death. systemic infection was proved by demonstrating the same pattern of fluorescein-labelled lectin staining of fungal elements in the tissues as was shown by the fungal isolates.19853857176
disseminated trichosporon capitatum infection in a patient with acute leukemia.disseminated trichosporon capitatum infection in a 14-year-old boy with acute lymphoblastic leukemia is described. t. capitatum causes opportunistic infection in immunocompromised hosts.19883422174
trichosporon capitatum fungemia and intravenous drug abuse. 19873423591
uncommon yeastlike zoopathogens and commercial systems for their identification.opportunistic infections caused by yeasts or yeastlike fungi have increased in incidence in recent years as a result of clinical and therapeutic factors. several formerly uncommon yeastlike zoopathogens--candida lusitaniae, candida paratropicalis (sucrose-negative variant of candida tropicalis), trichosporon beigelii, blastoschizomyces capitatus, and rhodotorula species--have been isolated from patients with invasive infections. the increased isolation of such opportunistic pathogens from a vari ...19873309664
ct findings in fungal opportunistic pneumonias: body and brain involvement.a population of 28 immunocompromised hosts with proved pulmonary infections by candida species (n = 18) or angioinvasive fungal pneumonias (aspergillus species, n = 7, mucor species n = 2, trichosporon capitatum n = 1) were retrospectively examined for any characteristic computed tomographic (ct) pattern. chest ct examination in angioinvasive fungal pneumonias (afp) showed in all cases nodules or mass-like infiltrates. the mass/nodules were surrounded by a halo of low attenuation in early scans ...19892804947
spontaneous pneumothorax complicating pulmonary mycetoma in patients with acute leukemia.pneumothorax caused by the rupture of a mycetoma into the pleural space is rarely reported in patients undergoing intensive cytotoxic therapy for hematologic malignancies. we reviewed 46 episodes of mycetoma that developed in 43 patients undergoing antineoplastic therapy; six (13%) of these episodes were further complicated by the occurrence of pneumothorax that developed after bone marrow recovery with return to normal granulocyte count. etiologic agents included aspergillus fumigatus, aspergil ...19902385767
blastoschizomyces capitatus: an emerging cause of invasive fungal disease in leukemia patients.blastoschizomyces capitatus (formerly named trichosporon capitatum or geotrichum capitatum) is a rare cause of invasive fungal disease in immunocompromised hosts. we retrospectively studied epidemiologic, clinical, pathologic, and microbiologic features of this infection during a 68-month period at the division of hematology of the university la sapienza in rome. twenty patients with evidence of b. capitatus were identified: 12 were infected, four were possibly infected, and four had evidence of ...19902385764
isolated meningitis caused by blastoschizomyces capitatus. 19902324536
disseminated trichosporon capitatum infection in a patient with acute leukemia undergoing bone marrow transplantation.a case of disseminated infection with trichosporon capitatum is reported in a 23-year-old patient with acute myeloid leukemia undergoing hla-mismatched bone marrow transplantation. he was receiving immunosuppressive therapy with cyclosporine and corticosteroids for acute graft-versus-host disease and he was severely neutropenic. while being treated with fluconazole for 28 days for an oropharyngeal candidiasis the patient developed a t. capitatum septicemia. he died despite receiving amphotericin ...19902252963
pathogenicity of trichosporon capitatum for normal and irradiated mice and the efficacy of miconazole on experimental systemic trichosporosis in mice.the authors describe the course of experimental trichosporosis in normal and x-irradiated icr mice after i.v. inoculation with trichosporon capitatum. the irradiated animals were considerably more sensitive to infection than normal animals. the ld50 challenge dose used was by approximately two orders lower (1 x 10(3) c.f.u. ml-1) in irradiated mice than in control animals. the histopathological examination of the internal organs of the infected mice demonstrated that the greatest tissue damage w ...19902103594
in-vitro comparative activity of fluconazole and other antifungal agents against blastoschizomyces capitatus.blastoschizomyces capitatus represents an emerging fungal pathogen in acute leukemia patients. the susceptibility to amphotericin b, 5-fluorocytosine, ketoconazole and fluconazole of nine clinical isolates was evaluated. a specific medium (high resolution medium) was used for testing fluconazole. this agent and 5-fluorocytosine were at least four- to eight-fold more active than amphotericin b and ketoconazole against all isolates but one.19912019857
in vitro susceptibility of 119 yeast isolates to fluconazole, 5-fluorocytosine, amphotericin b and ketoconazole.the in vitro activity of fluconazole was tested against 13 yeast species (119 strains) isolated from clinical specimens during a 3-month period. for comparative purposes, three other antifungal compounds (5-fluorocytosine, amphotericin b and ketoconazole) were also tested. the tests were carried out using a microautomated method previously developed in our laboratory. the method allowed us to determine the minimum inhibitory concentration (mic) of the four antifungal drugs used. for each of the ...19912013239
oral yeast flora of a population in an area of tanzania bordering an aids endemic zone.mouth swabs from 1,288 individuals in the north mara region of tanzania were cultured for yeasts. subjects were randomly selected from rural and urban areas, and a group of food handlers were also studied. yeasts were cultured from 407 (31.6%) and candida albicans from 141 (10.9%) subjects. a wide variety of other yeast species were also identified.19911800097
azole therapy for trichosporonosis: clinical evaluation of eight patients, experimental therapy for murine infection, and review.we studied the in vivo antifungal activity of azoles in humans and in a murine model of disseminated trichosporonosis. eight patients infected with trichosporon species were treated with fluconazole, sch 39304, or miconazole for 2-26 weeks. four patients had fungemia, two patients had disseminated trichosporonosis, and one patient each had soft-tissue infection and cystitis. response of trichosporonosis to azoles was seen in all eight patients, although one patient died with disseminated aspergi ...19921445976
catheter-associated septicaemia due to trichosporon capitatum. 19921362742
[trichosporon capitatum septicemia. apropos of 5 cases].invasive trichosporon capitatum infections are seldom reported. we present here five cases of septicemia. all patients had an acute myeloblastic leukemia and were severely neutropenic. they have also been treated before the onset of the fungal infection with broad-spectrum antibiotherapy and also with an oral azole antifungal agent. the role of this antifungal therapy in the development of t. capitatum infection is discussed. the prognosis of t. capitatum infections is severe. eight of the 10 pu ...19921340100
disseminated trichosporon capitatum infection in an immunosuppressed host.trichosporon is a frequent cause of superficial mycotic infections but has rarely been associated with invasive disease. a patient undergoing bone marrow transplantation who died from disseminated trichosporon capitatum infection with endocarditis is reported, and the clinical spectrum of human infection caused by fungi of this genus is reviewed. to our knowledge, this is the first reported case of clearly invasive disease caused by this specific organism and emphasizes the expanding spectrum of ...1977332101
[trichosporon capitatum as pathogen of dermatomycoses].three cases of dermatomcycosis are reported, caused by trichosporon capitatum, a yeast-like organism, belonging to genus trichosporon of the cryptococcaceae, which till now was isolated out of dermatological material only in a few cases. one of the lesions, characterized as "leuconychia mycotica", is a problematic task with regard to the treatment, for it is a professional infection in an offset-printer. a glycerol containing fluid for wiping his printing machine was detected as reservoir of yea ...1976136429
dna relatedness, taxonomy, and medical significance of geotrichum capitatum.among the clinical isolates hitherto identified as geotrichum capitatum, two groups were defined from dna-dna reassociation experiments. this confirms the existence of two closely related, human-pathogenic geotrichum species, namely, g. capitatum and g. clavatum. a third group of strains from cactus rots, though morphologically identical to g. capitatum, has a lower moles percent g + c of dna. the three groups can be recognized by a combination of morphological and physiological characters.19873611311
paravertebral abscess caused by trichosporon capitatum in a child with acute lymphoblastic leukaemia. 19958586852
evaluation of the updated vitek yeast identification data base.using 398 isolates of yeasts and yeastlike fungi comprising 9 genera and 26 species, as well as the hyphomycete geotrichum candidum and the achlorophyllous alga prototheca wickerhamii, we compared the api 20c yeast identification system with the modified vitek yeast identification system with an expanded data base. we found 11 discrepancies between the two systems: five (1.3%) of the isolates (blastoschizomyces capitatus, 1; candida albicans, 1; hansenula anomala, 1; rhodotorula minuta, 2) had b ...19902229376
disseminated geotrichum capitatum infection in a patient with acute myeloid leukemia.a case of invasive geotrichum capitatum infection is reported; a young patient had an acute leukemia for which he received a chemotherapy, and presented sepsis with blood cultures for geotrichum capitatum, namely dipodascus spicifer; this pathogen only described in cactus rot, is responsible for the first case of a human disseminated infection reported in literature. then he developed a splenic and epididymic infection, with positive cultures for geotrichum capitatum after splenectomy and castra ...19892615781
colonization and infection with trichosporon species in the immunosuppressed host.trichosporon beigelii and trichosporon capitatum have recently been recognized as systemic pathogens in the immunosuppressed host. we studied the incidence of colonization and systemic infection with these organisms in 353 highly immunocompromised patients over a 37-month period. thirteen patients (3.7%) had positive surveillance cultures for trichosporon species in stool, skin, or urine. three of the 13 patients developed systemic infections after having positive surveillance cultures. in two o ...19836827136
the new fungal opportunists are coming.frequent and prolonged exposure of immunocompromised patients to a variety of environmental conditions has resulted in the recognition of infections with new fungal opportunists. infections with fungi such as fusarium species, paecilomyces lilacinus, acremonium species, trichosporon beigelii, blastoschizomyces capitatus, malassezia furfur, penicillium marneffei, scedosporium prolificans, and other dematiaceous species have become significant problems in the treatment of immunocompromised hosts. ...19968722837
[on the problem of pathogenicity of the yeast fungus trichosporon capitatum in the respiratory tract of man. a contribution to the diagnosis of pulmonary mycoses]. 19655328034
[on the occurrence of trichosporon capitatum (diddens et lodder 1942) in human specimen]. 19675628416
trichosporon capitatum causing recurrent fungal endocarditis. 19817198299
[zinc consumption from the nutrient medium of trichosporon capitatum and aspergillus niger].the sorption capacity of the cultures trichosporon capitatum and aspergillus niger towards zinc dissolved in the culture liquid was studied by radio active labelling. the curves of sorption kinetics and the so-called sorption quasi-isotherms showing the dependence of zinc sorption by the microbial biomass upon zinc concentration in the liquid medium were derived. for the aspergillus niger culture at zinc concentrations of 0.5 to 52 mug/ml the sorption quasi-isotherm was linear. the zinc extracti ...19751239764
osteomyelitis and intervertebral discitis caused by blastoschizomyces capitatus in a patient with acute leukemia.we describe the first known case of vertebral osteomyelitis and discitis caused by blastoschizomyces capitatus in a leukemic patient and the results of therapy. we also reconfirm the microbiological characteristics which differentiate this species from other yeastlike pathogens.19948126186
[lung pathogenicity of trichosporon capitatum in man]. 19655854508
trichosporon capitatum: thrush-like oral infection, local invasion, fungaemia and metastatic abscess formation in a leukaemic patient.a thrush-like oral infection with subsequent alveolar abscess formation and a positive blood culture due to trichosporon capitatum developed in a patient with acute myelogenous leukaemia. later t. capitatum was identified by indirect immunofluorescence in multiple splenic abscesses. the infection was controlled by immediate aggressive treatment with amphotericin b, flucytosine and rifampicin and by splenectomy. this case of systemic t. capitatum infection resembles somewhat the invasive mycosis ...19836576066
disseminated geotrichum capitatum infection with predominant liver involvement in a patient with non hodgkin's lymphoma.geotrichum capitatum is an emerging opportunistic pathogen which causes invasive disease in immunocompromized patients. we describe a patient with non hodgkin's lymphoma and disseminated infection by g. capitatum with predominant liver involvement, which was proven by repeated positive blood cultures and a liver biopsy. staining liver biopsy demonstrated the presence of hyphal elements consistent with g. capitatum. combined antimycotic treatment with amphotericin b and 5-flucytosine did not erad ...19968870383
in vitro activity of the new triazole voriconazole (uk-109,496) against opportunistic filamentous and dimorphic fungi and common and emerging yeast pathogens.the in vitro antifungal activity of a new triazole derivative, voriconazole, was compared with those of itraconazole and amphotericin b against 67 isolates of aspergillus flavus, aspergillus fumigatus, bipolaris spp., fusarium oxysporum, fusarium solani, pseudallescheria boydii, rhizopus arrhizus, blastomyces dermatitidis, histoplasma capsulatum, and sporothrix schenckii. the in vitro activities of voriconazole were also compared with those of amphotericin b, fluconazole, and itraconazole agains ...19989431946
sordarins: in vitro activities of new antifungal derivatives against pathogenic yeasts, pneumocystis carinii, and filamentous 193663, gm 211676, gm 222712, and gm 237354 are new semisynthetic derivatives of the sordarin class. the in vitro antifungal activities of gm 193663, gm 211676, gm 222712, and gm 237354 against 111 clinical yeast isolates of candida albicans, candida kefyr, candida glabrata, candida parapsilosis, candida krusei, and cryptococcus neoformans were compared. the in vitro activities of some of these compounds against pneumocystis carinii, 20 isolates each of aspergillus fumigatus and aspergillus f ...19989797217
empirical liposomal amphotericin-b therapy in a neutropenic patient: breakthrough of disseminated blastoschizomyces capitatus infection.blastoschizomyces capitatus (trichosporon capitatum) is an uncommon fungal pathogen. infections have mostly been seen in immunocompromised patients and use of broad spectrum antibiotics was identified as a risk factor. treatment has been extremely difficult. a report is presented about a case of fatal b. capitatum infection with clinical septicemia and multiorgan failure during intravenous liposomal amphotericin b therapy.19968837396
relationship between cell counts in bovine milk and the presence of mastitis pathogens (yeasts and bacteria).bovine mastitis is an economically important disease in dairy industry and a variety of pathogen microorganisms are involved. the aa carried out a study to investigate the prevalence of yeasts and bacteria in milk samples (794) from dairy cows of umbria (central italy), belonging to 19 herds, and the relationship between cell counts in bovine milk and the presence of these pathogens. 29.7% milk samples were positive for pathogen microorganisms, of those 4.9% were positive for yeasts and bacteria ...19989588106
geotrichum capitatum septicaemia in neutropenic patients: case report and review of the literature.we report a case of systemic infection with geotrichum capitatum in a patient with acute myeloid leukaemia. three days before death, the patient developed acute renal failure, probably caused by occlusion of glomerula with hyphae of g. capitatum. up until now, prophylaxis and treatment of infections caused by geotrichum capitatum have not been established. however, the prophylactic administration of high-dose itraconazole and the therapeutic use of liposomal amphotericin b are subjects of discus ...19989670762
emergence of fluconazole-resistant strains of blastoschizomyces capitatus causing nosocomial infections in cancer patients.blastoschizomyces capitatus strains resistant to fluconazole were isolated in three cancer patients. all of the strains had identical genomic dna restriction profiles. our findings give evidence for the emergence of fluconazole-resistant b. capitatus and suggest a nosocomial acquisition emanating from a common source within the hospital environment.19968904454
cell wall preparations from environmental yeasts: effect on alveolar macrophage function in dust toxic syndrome (odts) is associated with inhalation of high concentrations of organic materials and is a noninfectious illness characterized by fever, malaise, myalgia, and neutrophilic inflammation of the lower respiratory tract. studies in our laboratory of fungi in fresh lumber have demonstrated that yeasts may predominate and have raised the issue of potential exposure of sawmill workers to yeasts. zymosan, a cell wall preparation from saccharomyces cerevisiae, is a potent stimu ...19989852493
pathogenicity of yeasts and algae isolated from bovine mastitis secretions in a murine model.the pathogenicity of strains of yeasts and algae isolated from bovine mastitis secretions was evaluated in immunosuppressed mice. strains of candida tropicalis (n = 3) were the most pathogenic, but all strains of geotrichum capitatum (n = 5) and the colourless alga prototheca zopfii (n = 5) were also lethal to mice at the highest dose of 1 x 10(7) cfu per mouse. reisolation of the inoculated micro-organisms and the occurrence of histopathological lesions within organs of mice challenged with 1 x ...19947845414
geotrichosis of oral mucosa.a livid, sharply defined enanthema of the oral mucosa with ulcerations on the soft palate in a patient presenting with de novo acute myeloid leukaemia with prolonged, therapy-induced granulocytopenia (< 0.5 nl-1 for 113 days!) was diagnosed as geotrichosis. geotrichum capitatum was identified both in vivo and in vitro. pneumonic infiltrates in the upper lobes of both lungs were treated with amphotericin b infusions. healing of the aforementioned enanthema was only achieved after addition of 5-fl ...19969009647
new aspects of emerging fungal pathogens. a multifaceted challenge.this article describes adventitious morphologic forms for species of fusarium, paecilomyces, acremonium, and scedosporium that can be easily mistaken on histologic, cytologic, and microbiologic examination for candida species. these forms appear to be correlated with, and may provide explanation for, positive blood cultures in disseminated infections with these species. adventitious histologic forms also are illustrated for blastoschizomyces capitatus. data from culture-proven mycoses for a 15-m ...19957671578
antifungal activity of the essential oil of agastache rugosa kuntze and its synergism with evaluate the fungitoxic activity of the essential oil of agastache rugosa alone and to determine its combination effect with ketoconazole against blastoschizomyces capitatus.200312535132
comparison of rapid yeast plus system with api 20c system for identification of common, new, and emerging yeast pathogens.the ability to identify yeast isolates by the new enzymatic rapid yeast plus system was compared to the ability to identify yeast isolates by the api 20c system. a total of 447 yeast isolates representing blastoschizomyces capitatus, 17 candida spp., 5 cryptococcus spp., geotrichum spp., 2 hanseniaspora spp., hansenula anomala, hansenula wingei, 3 rhodotorula spp., saccharomyces cerevisiae, sporobolomyces salmonicolor, trichosporon beigelii, and 2 prototheca spp. were evaluated. also, five quali ...19989542903
hematogenous trichosporonosis in cancer patients: report of 12 cases including 5 during prophylaxis with itraconazol.twelve cases of trichosporon spp. fungemias occurring in a national cancer institution within 10 years are described. the trend of hematogenous trichosporonosis within the last 10 years is increasing. while no cases occurred in 1988-1991, after 1991, trichosporon spp. was the most common species among non-candida spp. fungemias in 1993-1997. the 12 cases of fungemia included 5 that started while the patients were receiving prophylaxis with oral itraconazole, and 2 appeared despite empiric therap ...19999926973
invasive yeast infections other than candida spp. in acute leukaemia.during the last two decades, the treatment of leukaemia has changed significantly; increasing intensity of chemotherapy and bone marrow transplantation have lead to profound immunosuppression, prolonged stays in hospital, vascular catheterization, administration of broad spectrum antimicrobial agents and extensive use of prophylactic antifungal drugs. all but the last of these risk factors have increased the incidence of fungal infections in leukaemic patients and have significantly changed the ...199910204120
mycotic and algal bovine mastitis in denmark.a one-year examination of mammary secretions (n = 2,896) from danish cattle with clinical or subclinical mastitis revealed 45 strains of fungi and algae. the strains originated from 44 mammary secretions of 42 cows in 40 herds. the following species of fungi were identified: candida catenulata (n = 2), candida kefyr (n = 6), candida krusei (n = 17), candida rugosa (n = 6), candida tropicalis (n = 3), candida valida (n = 1), geotrichum capitatum (n = 5). the algal species prototheca zopfii was de ...19948068305
[geotrichum capitatum infection in a neutropenic patient. apropos of a case and review of the literature].geotrichum capitatum sepsis are rare, occurring exclusively in immunocompromised patients.19989775185
uncommon opportunistic fungi: new nosocomial threats.during the past two decades opportunistic fungal infections have emerged as important causes of morbidity and mortality in patients with severe underlying illnesses and compromised host defenses. while aspergillus and candida spp. collectively account for the majority of these infections, recent epidemiological trends indicate a shift towards infections by aspergillus spp., nonalbicans candida spp., as well as previously uncommon opportunistic fungi. apart from an expanding number of different z ...200111525222
multicenter comparison of the sensititre yeastone colorimetric antifungal panel with the national committee for clinical laboratory standards m27-a reference method for testing clinical isolates of common and emerging candida spp., cryptococcus spp., and other yeasts and yeast-like organisms.national committee for clinical laboratory standards (nccls) standard guidelines are available for the antifungal susceptibility testing of common candida spp. and cryptococcus neoformans, but nccls methods may not be the most efficient and convenient procedures for use in the clinical laboratory. mics of amphotericin b, fluconazole, flucytosine, itraconazole, and ketoconazole were determined by the commercially prepared sensititre yeastone colorimetric antifungal panel and by the nccls m27-a br ...19999986817
fungal urinary tract infections in patients at risk.fungal urinary tract infection (uti) represents a high-risk event in severely ill patients. its increasing incidence in recent years is associated with extensive and prolonged use of broad-spectrum antimicrobial agents, corticosteroids, immunosuppressive and cytotoxic drugs. other important risk factors comprise higher age, diabetes mellitus, chronic renal failure, hemodialysis, renal transplantation, structural or functional abnormalities of urinary tract with indwelling urinary catheter or nep ...199910394985
blastoschizomyces capitatus infection in acute leukemia patients.blastoschizomyces capitatus (bc), a filamentous fungus of genus trichosporum, is as an important opportunistic pathogen in the compromised host. within the past 10 years, 47 cases of bc infection have been published. most of the patients had acute leukemia (al) or related disorders and had received chemotherapy treatment. due to bc's resistance to currently used antifungal agents, this infection represents a therapeutic challenge and serious complication in the treatment of hematology malignanci ...200010975401
antifungal activities and cytotoxicity studies of six new 471552, gw 471558, gw 479821, gw 515716, gw 570009, and gw 587270 are members of a new family of sordarin derivatives called azasordarins. the in vitro activities of these compounds were evaluated against clinical isolates of yeasts, including candida albicans, candida non-albicans, and cryptococcus neoformans strains. activities against pneumocystis carinii, aspergillus spp., less common molds, and dermatophytes were also investigated. azasordarin derivatives displayed significant activities ...200111600368
onychomycosis caused by blastoschizomyces capitatus.blastoschizomyces capitatus was cultured from the nail of a healthy patient with onychomycosis. the identity of the isolate was initially established by standard methods and ultrastructural analysis and was verified by molecular probing. strains atcc 200929, atcc 62963, and atcc 62964 served as reference strains for these analyses. to our knowledge, this is the first case of nail infection secondary to paronychia caused by this organism reported in the english literature.199910449477
treatment of chronic disseminated geotrichum capitatum infection with high cumulative dose of colloidal amphotericin b and itraconazole in a leukaemia patient.a case of disseminated granulomatous geotrichum capitatum infection is reported. a young patient with blastic crisis of chronic myelogenous leukaemia developed septicaemia caused by g. capitatum in the post-chemotherapy aplastic phase. subsequently, disseminated infection of the liver, spleen, pancreas and kidneys was observed. treatment with high cumulative doses of a lipid formulation of amphotericin b (amphocil, 20.2 g in 11 weeks) and maintenance with itraconazole resolved clinical manifesta ...19958569813
adjuvant therapy with rhgm-csf for the treatment of blastoschizomyces capitatus systemic infection in a patient with acute myeloid leukemia.we report a patient with acute myeloid leukemia and blastoschizomyces capitatus sepsis who developed multiple abscesses when neutrophils recovered. the patient did not respond to antifungal therapy and her clinical condition showed an improvement only after rhgm-csf was added to the treatment.19968695721
evaluation of an electrochemical bioreactor system in the biotransformation of 6-bromo-2-tetralone to 6-bromo-2-tetralol.biotransformation of 6-bromo-2-tetralone (br-beta-tetralone) to 6-bromo-2-tetralol (br-beta-tetralol) by yeast cells of trichosporon capitatum (atcc 74312) and its partially purified br-beta-tetralone reductase was evaluated in an electrochemical bioreactor. the biotransformation rates and final product formation were significantly affected by substrate concentration, biomass and electric potential. at 2 g/l of substrate, the initial reaction rate and final product were increased by 35% and 15%, ...200111762596
disseminated blastoschizomyces capitatus infection in acute myeloblastic leukaemia. report of three cases.three new cases of blastoschizomyces capitatus infection occurring in neutropenic patients with acute myeloblastic leukaemia are reported. b. capitatus was isolated from blood cultures in all patients. all three patients were treated with amphotericin b, but only one was cured from the infection. our study confirms the emergence of b. capitatus as an opportunistic agent of disseminated fungal infection in leukaemic patients.19968829307
funguria in cancer patients: analysis of risk factors, clinical presentation and outcome in 50 patients.fifty cancer patients with funguria of > 10(5) cfu/ml, dysuria and leukocyturia were retrospectively analyzed for etiology, risk factors and outcome. in 72% of cases candida albicans and in 28% non-albicans candida spp. (candida krusei, candida tropicalis) and non-candida spp. yeasts (blastoschizomyces capitatus) were isolated. torulopsis glabrata was not found among these patients. the most frequent risk factors were: antibiotic therapy with more than one antibiotic agent (96%), concomitant fun ...19968875285
dipodascus capitatus, dipodascus spicifer and geotrichum clavatum: genomic characterization.the g + c contents of 25 strains of dipodascus capitatus, dipodascus spicifer and geotrichum clavatum were found to be heterogeneous on basis of derivative graphs of the melting profiles. strains showing similar derivative graphs of the melting curve exhibited high levels of dna homology (80-100%); strains showing dissimilar derivative graphs exhibited low levels of dna homology (5 to 45%). being considered separate taxa on basis of these parameters, d. capitatus, d. spicifer and g. clavatum cou ...199810081582
mandibular osteomyelitis caused by blastoschizomyces capitatus in a child with acute myelogenous leukemia.a 6-year-old girl with acute myelogenous leukemia (aml) developed fungal mandibular osteomyelitis during chemotherapy. blastoschizomyces capitatus was recognized histologically by its yeast-like morphology and formation of annelloconidia, and was confirmed by culture. the fungal osteomyelitis of the mandible was treated successfully with prolonged antifungal medication, extensive surgical debridement and an oral care program, without interrupting leukemia chemotherapy. b. capitatus osteomyelitis ...199910705698
case report. disseminated infection of blastoschizomyces capitatus in a patient with acute myelocytic leukaemia.blastoschizomyces capitatus infection in a 48-year-old man with acute myelocytic leukaemia is reported. a multiorgan involvement and fulminant course of the fungal infection resulted in the patient's death despite fluconazole prophylaxis, therapy with amphotericin b and administration of granulocyte colony-stimulating factor. predisposing factors to the infection, clinical relevance of surveillance strains and in vitro antifungal susceptibility testing are discussed.200111820266
comparison of updated vitek yeast biochemical card and api 20c yeast identification systems.the updated vitek yeast biochemical card (ybc) was compared with the api 20c by using 409 germ tube-negative yeasts and geotrichum spp. that were either clinical or proficiency sample isolates. the api 20c was the reference standard. the 409 isolates represented nine genera and 21 species. morphology agars were inoculated and interpreted for each isolate. the api 20c identified 406 isolates (99.3%), while the vitek ybc identified 367 (89.7%). both systems identified the majority of yeasts after ...19948051243
decaying wood in tree trunk hollows as a natural substrate for cryptococcus neoformans and other yeast-like fungi of clinical interest.the occurrence of cryptococcus neoformans var. neoformans and other yeast-like fungi of clinical interest in decaying wood inside tree trunk hollows, bark and other plant materials is reported. the var. neoformans was isolated from 3 of 45 (6.6%) wood and one of 390 eucalyptus bark samples. two of the positive wood samples came from a tree trunk hollow of butea monosperma (family: papilionaceae) growing in roshan ara garden, old delhi whereas the third was from a trunk hollow of tamarindus indic ...200111554580
the yeast species causing fungemia at a university hospital in riyadh, saudi arabia, during a 10-year period.this study is a retrospective investigation to determine the species of yeasts causing fungemia in a university hospital in saudi arabia during the years 1991-2000. a total of 189 episodes of fungemia were encountered, of which 121 (64%) occurred during 1991-1995, whereas only 68 cases (36%) were found between 1996 and 2000. overall, 50.3% episodes were due to candida albicans including five episodes of c. dubliniensis, followed by c. tropicalis (27%), c. parapsilosis (7.9%), c. glabrata (7.4%), ...200312950897
[antifungal susceptibility of emerging yeast pathogens].to study the antifungal susceptibility of emerging yeast pathogens to know their possible resistance under the need of applying a treatment.200111440661
in vitro susceptibility testing of geotrichum capitatum: comparison of the e-test, disk diffusion, and sensititre colorimetric methods with the nccls m27-a2 broth microdilution reference method.the in vitro activities of amphotericin b, flucytosine, fluconazole, itraconazole, and voriconazole against 23 isolates of geotrichum capitatum were determined by the national committee for clinical laboratory standards (nccls) m27-a2 microdilution method and the sensititre and agar diffusion methods. amphotericin b and voriconazole appeared to be the more active drugs. sensititre showed the highest rates of agreement with the nccls m27-a2 method.200314638517
blastoschizomyces capitatus infection in patients with leukemia: report of 26 cases.twenty-six cases of blastoschizomyces capitatus infection were diagnosed in 25 patients at 7 tertiary care hematology units in spain over a 10-year period. most patients (92%) had acute leukemia and developed infection during a period of severe and prolonged neutropenia. two patients had esophagitis, and the rest had invasive infection. fungemia (20 cases) was a common finding, with frequent visceral dissemination. the 30-day mortality associated with this infection was 52%, compared with 57% am ...200414727202
[persistent lung colonization by blastoschizomyces capitatus in patient with aids]. 200312681225
antifungal, antiprotozoal, cytotoxic and piscicidal properties of justicidin b and a new arylnaphthalide lignan from phyllanthus piscatorum.using activity against candida albicans as a lead, the bioactivity-guided fractionation of the dichloromethane extract of phyllanthus piscatorum led to the isolation of the arylnaphthalide lignan justicidin b (1), which was found to be present in high amounts, and a new c-11 hydroxylated derivative that we named piscatorin (2). we provide evidence that justicidin b (1) is the main active principle of p. piscatorum, showing the same biological effects that were found for the raw extracts. justici ...200312802722
overview of systemic fungal infections.a steady increase in the frequency of invasive fungal infections has been observed in the past 2 decades, particularly in immunosuppressed patients. in recipients of bone marrow transplants, candida albicans and aspergillus fumigatus remain the primary pathogens. in many centers, however, candida species other than c albicans now predominate, and many cases of aspergillosis are due to species other than a fumigatus. additionally, heretofore unrecognized and/or uncommon fungal pathogens are begin ...200111757845
an outbreak of dipodascus capitatus infection in the icu: three case reports and review of the literature.a mini epidemic of dipodascus capitatus (teleomorph of geotrichum capitatum) involving three cases is reported. the index case was pulmonary infection and a fulminant course of fungal infection, which resulted in the patient's death with acute myelocytic leukemia. in the other cases, the patients were simultaneously hospitalized, the first in the intensive care unit. in all cases, d. capitatus was identified in different samples (sputum, deep tracheal aspiration, blood, and urine) from each of t ...200415623948
geotrichum capitatum fungemia with skin lesions similar to varicella in a patient with acute lymphocytic leukemia.varicella-zoster virus (vzv) can cause increased morbidity and mortality in immunocompromised persons. varicella lesions (macules, papules and vesicles) often appear first on the scalp, face or trunk. we report the case of a leukemic patient who developed multiple maculopapular rashes with central vesicles after chemotherapy. the skin lesions were first noted on the scalp, face and then trunk and extremities. these manifestations were similar to those caused by vzv. both blood culture and skin v ...200415264705
blastoschizomyces capitatus infection after contamination of fluids for intravenous application.a six-month-old child died after infusion of fluids containing blastoschizomyces capitatus. this represents a fatality due to this organism in a human with no proven immunosuppression.19989916469
osteocartilaginous involvement in blastoschizomyces capitatus (trichosporon capitatum) infection in a bone marrow transplant recipient. 200414984489
enhanced heavy metal bioleaching efficiencies from anaerobically digested sewage sludge with coinoculation of acidithiobacillus ferrooxidans anyl-1 and blastoschizomyces capitatus y5.prolonged bioleaching period was required to remove heavy metals from anaerobically digested sewage sludge in the presence of low molecular weight organic acids. the purpose of the present study was therefore to enhance metal solubilization efficiencies through introducing organic acid-degrading microorganisms into this artificial bioleaching system. an acetic and propionic acid-degrading yeast blastoschizomyces capitatus y5 was successfully isolated from a local yuen long sewage sludge and it c ...200415580998
the use of adjuvant interferon-gamma therapy for hepatosplenic blastoschizomyces capitatus infection in a patient with leukemia.hepatosplenic fungal infections are a devastating complication of neutropenia. despite aggressive antifungal therapy, clinical response may be poor. we describe a case of hepatosplenic blastoschizomyces capitatus infection that responded to adjuvant interferon-gamma therapy.200011017841
invasive infections caused by blastoschizomyces capitatus and scedosporium spp.blastoschizomyces capitatus, scedosporium prolificans and s. apiospermum are emerging fungal pathogens that may cause disseminated disease in neutropenic patients. they can present as fever resistant to antibiotics and to wide-spectrum antifungal agents, although they may involve almost every organ. the proportion of recovery from blood cultures is high and they are characteristically resistant to most antifungal agents. prognosis is poor unless patients recover from neutropenia. voriconazole ha ...200414748804
[blastoschizomyces capitatus fungemia in a neutropenic patient]. 200011075489
genotyping and antifungal susceptibility profile of dipodascus capitatus isolates causing disseminated infection in seven hematological patients of a tertiary cases of disseminated infection due to dipodascus capitatus are reported. infections occurred in a hematological unit of a tertiary hospital during a period of 5 years. five cases were refractory to antifungal therapy. antifungal susceptibility testing of seven isolates was performed, and strains were typed by pcr fingerprinting with the core sequence of phage m13 and by random amplification of polymorphic dna with two primers, ap12h and w-80a. a very short range of mics of each antifungal ...200415071063
blastoschizomyces capitatus keratitis and melting in a corneal report: we present the first case, to our knowledge, of blastoschizomyces capitatus keratitis and melting in a corneal graft. an 80-year-old man was treated for a large, severe corneal abscess and melting in the corneal graft of his right eye. medical history was negative for hematologic disorders. urgent penetrating keratoplasty was performed. comments: corneal cultures grew b. capitatus. systemic fluconazole and systemic and topical amphotericin b treatment were started. three months afte ...200617224964
[a 19-year-old patient with acute promyelocytic leukemia and knee swelling].we report on a case of a 19-year-old female patient with acute promyelocytic leukemia suffering from febrile monarthitis of the right knee during neutropenia after consolidation chemotherapy caused by geotrichum capitatum. apparently this infection occurred due to a hematological reactivation since the patient had already developed geotrichum capitatum fungemia during induction therapy. under antimycotic therapy with voriconazole, flucytosine, and caspofungin as well as after two arthroscopic sy ...200616607504
multiple spondylodiscitis caused by blastoschizomyces capitatus in an allogeneic bone marrow transplantation recipient. 19989818677
blastoschizomyces capitatus pneumonia in an immunocompetent male.blastoschizomyces capitatus is an emerging fungal pathogen. it has been well characterized as a cause of local and disseminated disease in immunocompromised hosts, especially in the setting of neutropenia. we describe a case of b. capitatus pneumonia in an otherwise healthy man and review the clinical presentation, microbiologic characteristics, and treatment strategies for b. capitatus infections.200415301131
[pulmonary infection caused by blastoschizomices capitatus].geotrichum capitatum, now known as blastoschizomyces capitatus, can be responsible for several opportunistic infections (systemic infection or localized at lungs, liver, kidney, encephalitis or meningitis) in an immunocompromised host, especially in those patients affected by leukaemia or under immunosuppressive therapies. a 66-year-old woman with polimyosite under steroid and immunosuppressant therapy was hospitalized in icu for an acute respiratory distress with moderate hypoxaemia and normoca ...200516397422
incidence and management of proven and probable fungal infections in patients with acute leukemia: a single center experience.the incidence of fungal infections and the role of liposomal amphotericin b (ambisome) in proven and probable infections were evaluated in acute leukemic patients, intolerant to conventional amphotericin b. during 1999-2002, 307 febrile episodes occurred in 231 patients. fungi were responsible for 3% of bloodstream infections. ambisome was employed in 5 fungal sepsis (1 candida albicans, 1 c. famata, 1 c. tropicalis, 1 c. krusei, 1 geotrichum capitatum) 2 aspergillosis, 2 probable fungal pneumon ...200415700847
geotrichum capitatum fungemia in a patient with acute myeloid leukemia: case report. 200312962373
fatal disseminated blastoschizomyces capitatus (geotrichum capitatum) in a patient with relapse of acute lymphoblastic leukaemia. 200516194836
slime production by clinical isolates of blastoschizomyces capitatus from patients with hematological malignancies and catheter-related order to expand the present knowledge of the pathogenic potential of blastoschizomyces capitatus in central venous catheter (cvc)-related bloodstream infections, six strains of the organism recovered from three leukemic patients with cvc-related fungemia in different years were investigated. isolates and control strains were tested for their genetic relatedness and for their ability to produce slime in glucose-containing solutions. dna restriction enzyme analysis revealed that all strains of ...200415368097
invasive infections caused by trichosporon species and geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from italy and review of the literature.trichosporonosis is an uncommon but frequently fatal mycosis in immunocompromised patients. a multicenter retrospective study was conducted to characterize cases of proven or probable invasive trichosporonosis diagnosed over the past 20 years in italian patients with hematological diseases. of the 52 cases identified, 17 were classified as trichosporon sp. infections and 35 were attributed to geotrichum capitatum. acute myeloid leukemia accounted for 65.4% of the cases. the incidence rates of tr ...200515815003
safety assessment of dairy microorganisms: geotrichum candidum.geotrichum candidum is a ubiquitous filamentous yeast-like fungus commonly isolated from soil, air, water, milk, silage, plant tissues, digestive tract in humans and other mammals. this species is widely used as adjunct culture in the maturation of cheese. the genus geotrichum is composed of 18 species. a recent taxonomic revision concluded that the old galactomyces geotrichum/g. candidum complex contained four separate species of which galactomyces candidus sp. nov./g. candidum. m13 primer can ...200817869364
a case of oral geotrichosis caused by geotrichum capitatum in an old patient.geotrichosis is an uncommon fungal infection. geotrichum capitatum is commonly acknowledged as an opportunistic fungal pathogen that causes systemic geotrichosis in immunocompromised patients, especially patients with acute leukemia and severe neutropenia. here, we report a case of oral geotrichosis caused by g. capitatum in an old patient with no hematological malignancies. fungal cells were detected in clinical specimens obtained with oral swabs using the koh technique. yeast colonies with per ...200717881872
[in vitro activity of posaconazole against yeasts isolated in blood cultures].the in vitro activity of posaconazole against candida species isolated from blood cultures and the influence of incubation time was studied and compared with that of fluconazole. a total of 112 isolates were studied: 32 candida albicans, 33 c. parapsilosis, 17 c. tropicalis, 8 c. glabrata, 8 c. guilliermondii, 3 c. famata, 2 c. lusitaniae, 1 c. lipolytica, 1 c. inconspicua, 1 c. lambica, 3 saccharomyces cerevisiae, 1 blastoschizomyces capitatus, 1 geotricum spp. and 1 pichia omheri. the mic was ...200212587038
[the fungicidal activity and paradoxical effect of caspofungin against yeast. influence of culture medium and incubation time].the effect of culture medium and incubation time on the fungicidal activity of caspofungin and on the frequency of paradoxical effect has been studied in 144 blood culture isolates (42, candida tropicalis, 32 candida glabrata, 21 candida krusei, 20 candida parapsilosis, 11 candida guilliermondii, 4 candida famata, 3 candida lusitaniae, 3 blastoschizomyces capitatus, 2 saccharomyces cerevisiae, 2 yarrowia lipolytica, 1 candida inconspicua, 1 candida lambica, 1 candida sake y 1 pichia ohmeri). the ...200718563217
opportunistic infections in polymyositis and assess prevalence and characteristics of opportunistic infections in patients with polymyositis/dermatomyositis (pm/dm). to determine the predictive values for opportunistic infections on clinical presentation, biochemical findings, and paraclinical features of pm/dm to detect patients at risk of opportunistic infections.200515818648
purification and characterization of alcohol dehydrogenase reducing n-benzyl-3-pyrrolidinone from geotrichum capitatum.(s)-n-benzyl-3-pyrrolidinol is widely used in the synthesis of pharmaceuticals as a chiral building block. we produced 30 mm (s)-n-benzyl-3-pyrrolidinol (enantiometric excess > 99.9%) from the corresponding ketone n-benzyl-3-pyrrolidinone with more than 99.9% yield in 28 h of the resting-cell reaction of geotrichum capitatum jcm 3908. nad(+)-dependent alcohol dehydrogenase reducing n-benzyl-3-pyrrolidinone from g. capitatum jcm 3908 was purified to homogeneity by ammonium sulfate fractionation a ...200717368401
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