| evidence of human infection by a new mammarenavirus endemic to southeastern asia. | southeastern asia is a recognised hotspot for emerging infectious diseases, many of which have an animal origin. mammarenavirus infections contribute significantly to the human disease burden in both africa and the americas, but little data exists for asia. to date only two mammarenaviruses, the widely spread lymphocytic choriomeningitis virus and the recently described wēnzhōu virus have been identified in this region, but the zoonotic impact in asia remains unknown. here we report the presence ... | 2016 | 27278118 |
| effects of mammarenavirus infection (wēnzhōu virus) on the morphology of rattus exulans. | the circulation of mammarenaviruses in rodent populations of the mekong region has recently been established, with a genetic variant of wēnzhōu virus, cardamones virus, detected in two rattus species. this study tests the potential teratogenic effects of wēnzhōu infection on the development of a murid rodent, rattus exulans. using direct virus detection, morphological records and comparative analyses, a link was demonstrated between host infection status and host morphologies (the spleen irrespe ... | 2017 | 28554857 |
| genomic characterization of wenzhou mammarenavirus detected in wild rodents in guangzhou city, china. | wenzhou mammarenavirus (wenv) is a zoonotic pathogen newly discovered in east and southeast asia. wenv has been found in wild rodent animals around the world while its standing is barely understood in guangzhou city, where is known as a region of outbreak hotspot for zoonotic emerging infectious diseases. to investigate the prevalence and genomic characteristics of mammarenavirus in guangzhou city, lung tissue samples from wild rodent species were collected from five districts of guangzhou city ... | 2021 | 34179329 |
| virome profiling of rodents in xinjiang uygur autonomous region, china: isolation and characterization of a new strain of wenzhou virus. | rodents, as the most diverse and widest distributed mammals, are a natural reservoir of many zoonotic viruses. however, little is known about the viral diversity harbored by rodents in china. here we performed viral metagenomic analyses of 314 wild rodents covering 7 species, sampled in north-western china. we also conducted a systematic virological characterization of a new wenzhou virus (wenv) isolate, qarn1, from a brown rat (rattus norvegicus). full genomic and phylogenetic analyses showed t ... | 2019 | 30685659 |
| [genomic analysis of wenzhou virus in rodents from zhejiang province]. | objective: arenavirus is a negative single-stranded rna virus and an important human pathogen, mainly harbored and transmitted by rodents, causing severe diseases, including hemorrhagic fever and encephalitis. following the discovery of a novel pathogenic arenavirus (wenzhou virus, wenv), the prevalence of wenv in local small rodents was investigated. methods: by using rt-pcr, wenv was screened in 48 and 156 rodents sampled from wenzhou and longquan, respectively. results: consequently, wenv was ... | 2017 | 28329945 |
| complete genome sequence of a novel variant of wenzhou mammarenavirus. | wenzhou mammarenavirus (wenv) is a novel species of arenavirus that was first detected in china. we report here a novel wenv variant (wenv g107) from liver samples of rattus norvegicus that shares 84.7% to 86.8% (large [l] segment) and 84.2% to 87.8% (small [s] segment) nucleotide sequence identity with its closest relative. the genomic characteristics were analyzed based on the whole genome of wenv g107. | 2017 | 29167248 |
| isolation and characterization of a novel arenavirus harbored by rodents and shrews in zhejiang province, china. | to determine the biodiversity of arenaviruses in china, we captured and screened rodents and shrews in wenzhou city, zhejiang province, a locality where hemorrhagic fever diseases are endemic in humans. accordingly, arenaviruses were detected in 42 of 351 rodents from eight species, and in 12 of 272 asian house shrews (suncus murinus), by rt-pcr targeting the l segment. from these, a single arenavirus was successfully isolated in cell culture. the virion particles exhibited a typical arenavirus ... | 2015 | 25506671 |