| effects of triamcinolone acetonide on experimental oral candidiasis in monkeys. | thirteen adult monkeys (macaca irus) were infected with candida albicans by inoculating the microorganisms under an acrylic plate covering the palatal mucosa. six of the monkeys were treated with the steroid triamcinolone acetonide intramuscularly for 2 weeks before and 2 weeks after inoculation. the palatal mucosa was studied clinically and histologically at weekly or biweekly intervals for up to 5 months after inoculation. the cellular immune response was studied using the direct leukocyte mig ... | 1975 | 1056095 |
| primary structure and anticandidal activity of the major histatin from parotid secretion of the subhuman primate, macaca fascicularis. | a major macaque histatin (m-histatin 1) from the parotid secretion of the subhuman primate, macaca fascicularis, was isolated by gel filtration on bio-gel p-2 and purified to homogeneity by reversed-phase high-performance liquid chromatography on a tsk-ods c18 column. the complete amino acid sequence of m-histatin 1, determined by automated edman degradation, is: (formula; see text) m-histatin 1 contains 38 amino acid residues, a phosphoserine at residue 2, has a molecular weight of 4881.8, a ca ... | 1990 | 2229609 |
| microbicidal activity of octenidine hydrochloride, a new alkanediylbis[pyridine] germicidal agent. | the potential of octenidine hydrochloride (win 41464-2) as a topical microbicide was measured both by in vitro death kinetics and reductions in numbers of bacteria on the skin of cynomolgus monkeys. semilogarithmic survival curves were plotted to measure the microbicidal activity of various concentrations of octenidine against staphylococcus aureus. the microbicidal activity of octenidine was also determined for staphylococcus epidermidis, proteus mirabilis, streptococcus pyogenes, klebsiella pn ... | 1985 | 3909955 |
| preclinical development of keliximab, a primatized anti-cd4 monoclonal antibody, in human cd4 transgenic mice: characterization of the model and safety studies. | the preclinical safety assessment of biopharmaceuticals necessitates that studies be conducted in species in which the products are pharmacologically active. monoclonal antibodies are a promising class of biopharmaceuticals for many disease indications; however, by design, these agents tend to have limited species cross-reactivity and tend to only be active in primates. keliximab is a human-cynomolgus monkey chimeric (primatized) monoclonal antibody with specificity for human and chimpanzee cd4. ... | 2000 | 10918514 |
| animal pharmacokinetics and interspecies scaling of sordarin derivatives following intravenous administration. | sordarin derivatives constitute a new group of synthetic antifungal agents that selectively inhibit fungal protein synthesis. they have demonstrated in vitro activity against the most important fungal pathogens, both yeast and filamentous. this new family of compounds has also shown in vivo activity against murine candida albicans, histoplasma capsulatum, and coccidioides immitis experimental infections, as well as against pneumocystis carinii pneumonia in rats. after intravenous dosing in anima ... | 2001 | 11557470 |
| practical aspects of including functional endpoints in developmental toxicity studies. case study: immune function in hucd4 transgenic mice exposed to anti-cd4 mab in utero. | keliximab is a human-cynomolgus monkey chimeric (primatized) monoclonal antibody with specificity for human and chimpanzee cd4. as the preclinical safety assessment of biopharmaceuticals requires evaluation in pharmacologically responsive species, comprehensive toxicology studies, including reproductive toxicity, of this antibody were conducted in a human cd4 transgenic mouse model. the reproductive toxicology studies included a pre- and postnatal development study that incorporated immunotoxico ... | 2002 | 12458908 |
| effects of positively selected sequence variations in human and macaca fascicularis beta-defensins 2 on antimicrobial activity. | the evolution of orthologous genes coding for beta-defensin 2 (bd2) in primates has been subject to positive selection during the divergence of the platyrrhines from the catarrhines and of the cercopithecidae from the hylobatidae, great apes, and humans. three peptides have been selected for a functional analysis of the effects of sequence variations on the direct antimicrobial activity: human bd2 (hbd2), macaca fascicularis bd2 (mfabd2), and a variant of the human peptide lacking asp(4), (-d)hb ... | 2004 | 14742239 |
| lymphocyte depletion after alemtuzumab induction disrupts intestinal fungal microbiota in cynomolgus monkeys. | the interactions of specific fungal phylotypes with immune cells have been recently documented; however, little is known whether gut fungal microbiota is influenced by aberrant immune response in immunosuppressive state. this study aimed to define the biologic impact of lymphocyte depletion on gut fungal microbiota and their relationship. | 2014 | 25136848 |
| severe acquired idiopathic thrombocytopenia in a female cynomolgus macaque (macaca fascicularis). | a 4-y-old female cynomolgus macaque presented for veterinary evaluation prior to placement in a preclinical study showed markedly low platelet counts that continued to decrease over time. physical examination over the next several days showed areas of pale red discoloration in forelimbs, anterior thorax, and inguinal area and multifocal pinpoint areas of erythema or scabs. an area of dark red discoloration approximately 2 cm in diameter on the dorsal surface of the tongue was discovered on day 9 ... | 2015 | 26141452 |