| synthesis of bovine growth hormone in primates by using a herpesvirus vector. | a strain of herpesvirus saimiri containing a bovine growth hormone (bgh) gene under the control of the simian virus 40 (sv40) late-region promoter was constructed. this strain, bgh-z20, was replication competent and stably harbored the bgh gene upon serial passage. nonpermissive marmoset t cells persistently infected with bgh-z20 produced a 0.9-kilobase rna which contained all of the bgh exon sequences and appeared to initiate within the sv40 promoter region. however, in permissively infected ow ... | 1985 | 3016514 |
| owl monkey astrocytoma cells in culture spontaneously produce infectious jc virus which demonstrates altered biological properties. | a tumor cell suspension of an explanted jc virus (jcv)-induced owl monkey glioblastoma was inoculated intracranially into four recipient juvenile owl monkeys. twenty-eight months following inoculation one owl monkey developed a glioblastoma, which was explanted into tissue culture. dna from both the tumor tissue and tumor cells in culture hybridized to a jcv dna probe by southern analysis, indicating that free, as well as integrated, viral dna may be present. at the time of the second culture pa ... | 1987 | 3033272 |