| xanthocillin x monomethyl ether, a potent inhibitor of prostaglandin biosynthesis. | xanthocillin x monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of dichotomomyces cejpii. the compound inhibited prostaglandin synthesis from 14c-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 microm, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 microm. the inhibition of xanthocillin x monomethyl ether was reversible. of the enzymatic steps involved in the synthesis of prostaglan ... | 1981 | 7333967 |
| heat resistance of fungi from soil. | the survival of fungi from soil samples has been investigated after exposure to temperatures of 60, 70, 80 and 90 degrees c in sabouraud agar. the least resistant fungi surviving 60 degrees c for 60 min were the aspergillus (a.) niger group, chaetomium spp, penicillium spp, and scytalidium lignicola. none of these survived 70 degrees c for 10 min. the next group surviving 70 degrees c for 60 min included the a. glaucus group, byssochlamys nivea, dichotomomyces cejpii, gelasinospora spp, rhizocto ... | 1993 | 8217516 |
| antibiotic secondary metabolites of dichotomomyces cejpii. | nine fungal strains of dichotomomyces cejpii were studied for their ability to produce antibiotic metabolites. it was found that they produced secondary exo- and endometabolites with antimicrobial activity against gram-negative and gram-positive bacteria, yeasts and moulds and with a toxic effect against animal organs in vitro. detailed chemical characterization of these active principles need to be carried out. | 1999 | 10823183 |
| a novel indole-diterpenoid, jbir-03 with anti-mrsa activity from dichotomomyces cejpii var. cejpii nbrc 103559. | a new indole-diterpene, jbir-03 (1), was isolated from the fungus dichotomomyces cejpii var. cejpii nbrc 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-mrsa (methicillin-resistant staphylococcus aureus) activity and antifungal activity against apple valsa canker-causing fungus, valsa ceratosperma, while it exhibited no toxicity towards human cancer cells. | 2007 | 17965481 |
| heat resistant fungi isolated from soil. | the thermal death time values (tdt) were estimated for dichotomomyces cejpii, gilmaniella humicola, talaromyces avellaneus and talaromyces bacillisporus isolated from soil. tdt values were compared with the tdt values of the known heat-resistant species, byssochlamys nivea, neosartorya fischeri and talaromyces flavus. all species studied showed considerable heat resistance. the most resistant species talaromyces avellaneus (172 cfu, initial concentration) of the isolates with unknown heat resist ... | 1994 | 7986681 |
| heat-resistant fungi in the soil. | the occurrence of heat-resistant fungi has been demonstrated in samples of soil from the slovak republic. the heat-resistant species isolated were byssochlamys nivea, dichotomomyces cejpii, eupenicillium baarnense, neosartorya fischeri, talaromyces avellaneus, tal. bacillisporus, tal. emersonii, tal. flavus, tal. trachyspermus, tal. wortmanii, botryotrichum piluliferum, gilmaniella humicola and nodulisporium sp. some of them were isolated for the first time from czechoslovakian soil. for the var ... | 1992 | 1445767 |
| diverse secondary metabolites from the marine-derived fungus dichotomomyces cejpii f31-1. | by adding l-tryptophan and l-phenylalanine to gpy medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus dichotomomyces cejpii f31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. among these compounds, four amides dichotomocejs a-d (1-4), one polyketide dichocetide a (5), and two diketopipe ... | 2017 | 29104243 |
| toxinogenicity of heat-resistant fungi detected by a bio-assay. | the ciliostatic activity of exo- and endometabolites of 125 (100%) heat-resistant fungal isolates was evaluated in vitro by a bioassay on tracheal tissue cultures of 1 day old chicks. for 11 (9%) of the isolates investigated chloroform-extractable secondary metabolites were detected in the medium. for 29 (23%) they were detected in mycelium and spores and for 25 (20%) they were detected in the medium, mycelium and spores at the same time. especially dichotomomyces cejpii and eupenicillium baarne ... | 1997 | 9217113 |
| indoloditerpenes from a marine-derived fungal strain of dichotomomyces cejpii with antagonistic activity at gpr18 and cannabinoid receptors. | a marine-derived strain of dichotomomyces cejpii produces the new compounds emindole sb beta-mannoside (1) and 27-o-methylasporyzin c (2), as well as the known indoloditerpenes jbir-03 (3) and emindole sb (4). indole derivative 1 was found to be a cb2 antagonist, while 2 was identified as the first selective gpr18 antagonist with an indole structure. compound 4 was found to be a nonselective cb1/cb2 antagonist. the new natural indole derivatives may serve as lead structures for the development o ... | 2014 | 24471526 |
| bioprospection of cytotoxic compounds in fungal strains recovered from sediments of the brazilian coast. | the cytotoxic activities of extracts (50 μg/ml) from 48 fungal strains, recovered from sediments of pecém's offshore port terminal (northeast coast of brazil), against hct-116 colon cancer cell lines were investigated. the most promising extract was obtained from strain brf082, identified as dichotomomyces cejpii by phylogenetic analyses of partial rpb2 gene sequence. thus, it was selected for bioassay-guided isolation of the cytotoxic compounds. large-scale fermentation of brf082 in potato dext ... | 2015 | 25766916 |
| epipolythiodiketopiperazines from the marine derived fungus dichotomomyces cejpii with nf-κb inhibitory potential. | the ascomycota dichotomomyces cejpii was isolated from the marine sponge callyspongia cf. c. flammea. a new gliotoxin derivative, 6-acetylmonodethiogliotoxin (1) was obtained from fungal extracts. compounds 2 and 3, methylthio-gliotoxin derivatives were formerly only known as semi-synthetic compounds and are here described as natural products. additionally the polyketide heveadride (4) was isolated. compounds 1, 2 and 4 dose-dependently down-regulated tnfα-induced nf-κb activity in human chronic ... | 2015 | 26258781 |
| aβ-42 lowering agents from the marine-derived fungus dichotomomyces cejpii. | the ascomycete dichotomomyces cejpii was isolated from the marine sponge callyspongia cf. c. flammea. three new steroids (1-3), two of which are present as glycosides, with an untypical pattern of carbon-carbon double bounds, were obtained from fungal extracts, as well as the known xanthocillin x dimethyl ether (4). compounds 2 and 4 were evaluated in an alzheimer's disease cellular assay and found capable of preventing the enhanced production of amyloid β-42 in aftin-5 treated cells. aβ-42 lowe ... | 2015 | 26440473 |
| dichotocejpins a-c: new diketopiperazines from a deep-sea-derived fungus dichotomomyces cejpii fs110. | three new diketopiperazines, dichotocejpins a-c (1-3), together with eight known analogues (4-11), were isolated from the culture of the deep-sea sediment derived fungus dichotomomyces cejpii fs110. their structures, including absolute configurations, were elucidated by a combination of hresims, nmr, x-ray crystallography, and ecd calculations. compounds 4-6, 10-11 showed significant cytotoxic activities against mcf-7, nci-h460, hepg-2, and sf-268 tumor cell lines. compound 1 exhibited excellent ... | 2016 | 27618072 |
| soil fungi: their potential use as a forensic tool. | as a grave is an anomalous environment and differs from its surroundings, criminal investigators employ different techniques for locating, recovering, and analyzing clandestine graves. in this study were identified the fungi found in the soil under corpses in decomposition with an aim at relating the copresence of human remains and different fungal species. were isolated the fungi in three ways: soil washing, serial dilutions, and moist chamber growth. dichotomomyces cejpii, talaromyces trachysp ... | 2014 | 24502190 |