single- and multiple-clade influenza a h5n1 vaccines induce cross protection in ferrets. | the rapid evolution, genetic diversity, broad host range, and increasing human infection with avian influenza a (h5n1) viruses highlight the need for an efficacious cross-clade vaccine. using the ferret model, we compared induction of cross-reactive immunity and protective efficacy of three single-clade h5n1 vaccines and a novel multiple-clade h5n1 vaccine, with and without mf59 adjuvant. reverse genetics (rg) was used to generate vaccine viruses containing the hemagglutinin (ha) and neuraminida ... | 2009 | 19406182 |