| viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection. | avian bornaviruses are causative agents of proventricular dilatation disease (pdd), a chronic neurologic and often fatal disorder of psittacines including endangered species. to date no causative therapy or immunoprophylaxis is available. our previous work has shown that viral vector vaccines can delay the course of homologous bornavirus challenge infections but failed to protect against pdd when persistent infection was not prevented. the goal of this study was to refine our avian bornavirus va ... | 2017 | 28017426 |
| viral vector vaccines expressing nucleoprotein and phosphoprotein genes of avian bornaviruses ameliorate homologous challenge infections in cockatiels and common canaries. | avian bornaviruses are causative agents of proventricular dilatation disease (pdd), an often fatal disease of parrots and related species (order psittaciformes) which is widely distributed in captive psittacine populations and may affect endangered species. here, we established a vaccination strategy employing two different well described viral vectors, namely recombinant newcastle disease virus (ndv) and modified vaccinia virus ankara (mva) that were engineered to express the phosphoprotein and ... | 2016 | 27830736 |
| plasma protein, haematologic and blood chemistry changes in african grey parrots (psittacus erithacus) experimentally infected with bornavirus. | bornaviruses are considered to be the causative agent of proventricular dilatation disease (pdd) in psittacine birds. in order to detect haematological and blood chemistry changes during the development of pdd and a possible correlation with clinical signs and the virological status, six african grey parrots (psittacus erithacus) were experimentally infected with parrot bornavirus 4 (pabv-4) by subcutaneous route. all six parrots developed clinical signs of varying extent and successful infectio ... | 2017 | 28488446 |
| ribavirin inhibits parrot bornavirus 4 replication in cell culture. | parrot bornavirus 4 is an etiological agent of proventricular dilatation disease, a fatal neurologic and gastrointestinal disease of psittacines and other birds. we tested the ability of ribavirin, an antiviral nucleoside analog with antiviral activity against a range of rna and dna viruses, to inhibit parrot bornavirus 4 replication in duck embryonic fibroblast cells. two analytical methods that evaluate different products of viral replication, indirect immunocytochemistry for viral specific nu ... | 2015 | 26222794 |
| bornaviruses in naturally infected psittacus erithacus in portugal: insights of molecular epidemiology and ecology. | background: the genus orthobornavirus comprises non-segmented, negative-stranded rna viruses able to infect humans, mammals, reptiles and various birds. parrot bornavirus 1 to 8 (pabv-1 to 8) causes neurological and/or gastrointestinal syndromes and death on psittacines. we aimed to identify and to produce epidemiologic knowledge about the etiologic agent associated with a death of two female psittacus erithacus (grey parrot). methods and results: both parrots were submitted for a complete stand ... | 2019 | 31741722 |
| detection and phylogenetic analysis of parrot bornavirus 4 identified from a swedish blue-winged macaw (primolius maracana) with unusual nonsuppurative myositis. | background: the genus orthobornavirus comprises rna viruses infecting humans, mammals, birds and reptiles, where parrot bornavirus 1 to 8 causes fatal neurological and/or gastrointestinal syndromes in psittacines. there is, to the best of our knowledge, no publication describing avian bornaviruses in pet parrots in sweden. we aimed to identify and to produce epidemiologic knowledge about the etiologic agent associated with a history of severe weight loss and death of a primolius maracana.methods ... | 2019 | 30598738 |
| monitoring of free-ranging and captive psittacula populations in western europe for avian bornaviruses, circoviruses and polyomaviruses. | avian pathogens such as bornaviruses, circoviruses and polyomaviruses are widely distributed in captive collections of psittacine birds worldwide and can cause fatal diseases. in contrast, only little is known about their presence in free-ranging psittacines and their impact on these populations. rose-ringed parakeets (psittacula krameri) and alexandrine parakeets (psittacula eupatria) are non-native to europe, but have established stable populations in parts of western europe. from 2012-2017, w ... | 2020 | 31617746 |
| recombinant modified vaccinia virus ankara (mva) vaccines efficiently protect cockatiels against parrot bornavirus infection and proventricular dilatation disease. | parrot bornaviruses (pabvs) are the causative agents of proventricular dilatation disease (pdd), a chronic and often fatal neurologic disorder in psittaciformes. the disease is widely distributed in private parrot collections and threatens breeding populations of endangered species. thus, immunoprophylaxis strategies are urgently needed. in previous studies we demonstrated a prime-boost vaccination regime using modified vaccinia virus ankara (mva) and newcastle disease virus (ndv) constructs exp ... | 2019 | 31817690 |
| age-dependent development and clinical characteristics of an experimental parrot bornavirus-4 (pabv-4) infection in cockatiels (nymphicus hollandicus). | parrot bornavirus (pabv) is a pathogen often found in psittacine populations. infected, clinically healthy carrier birds are of major importance for epidemiology, but the underlying pathomechanism of this carrier status is poorly understood. the age, implying the maturation status of the immune system, at the time of infection might be significant for the clinical outcome. therefore, two groups of 11 cockatiels of different ages (adult and newly hatched) were inoculated with a pabv-4 isolate int ... | 2021 | 33215512 |
| wounds as the portal of entrance for parrot bornavirus 4 (pabv-4) and retrograde axonal transport in experimentally infected cockatiels (nymphicus hollandicus). | in this study, we investigated the natural route of infection of psittacine bornavirus (pabv), which is the causative agent of proventricular dilatation disease (pdd) in psittacines. we inoculated two infection groups through wounds with a pabv-4 isolate. in nine cockatiels (nymphicus hollandicus) we applied a virus suspension with a titer of 103 50% tissue culture infection dose (tcid50) via palatal lesions (group p, p1-9). in a second group of three cockatiels, we applied a virus suspension wi ... | 2020 | 33205181 |