| parrot bornavirus-2 and -4 rna detected in wild bird samples in japan are phylogenetically adjacent to those found in pet birds in japan. | bornaviruses (family bornaviridae) are non-segmented negative-strand rna viruses. avian bornaviruses (abvs), which are causative agents of proventricular dilatation disease, are a genetically diverse group with at least 15 genotypes, including parrot bornaviruses (pabvs) and aquatic bird bornavirus 1(abbv-1). borna disease virus 1(bodv-1), which infects mammals and causes neurological diseases, has also been reported to infect avian species, although the numbers of the cases have been markedly f ... | 2015 | 26315330 |
| viral vector vaccines protect cockatiels from inflammatory lesions after heterologous parrot bornavirus 2 challenge infection. | avian bornaviruses are causative agents of proventricular dilatation disease (pdd), a chronic neurologic and often fatal disorder of psittacines including endangered species. to date no causative therapy or immunoprophylaxis is available. our previous work has shown that viral vector vaccines can delay the course of homologous bornavirus challenge infections but failed to protect against pdd when persistent infection was not prevented. the goal of this study was to refine our avian bornavirus va ... | 2017 | 28017426 |
| phylogenetic analysis supports horizontal transmission as a driving force of the spread of avian bornaviruses. | avian bornaviruses are a genetically diverse group of viruses initially discovered in 2008. they are known to infect several avian orders. bornaviruses of parrots and related species (psittaciformes) are causative agents of proventricular dilatation disease, a chronic and often fatal neurologic disease widely distributed in captive psittacine populations. although knowledge has considerably increased in the past years, many aspects of the biology of avian bornaviruses are still undiscovered. in ... | 2016 | 27537693 |
| from nerves to brain to gastrointestinal tract: a time-based study of parrot bornavirus 2 (pabv-2) pathogenesis in cockatiels (nymphicus hollandicus). | parrot bornaviruses (pabvs) are the causative agents of proventricular dilatation disease, however key aspects of its pathogenesis, such as route of infection, viral spread and distribution, and target cells remain unclear. our study aimed to track the viral spread and lesion development at 5, 10, 20, 25, 35, 40, 60, 80, 95 and 114 dpi using histopathology, immunohistochemistry, and rt-pcr. after intramuscular inoculation of parrot bornavirus 2 (pabv-2) in the pectoral muscle of cockatiels, this ... | 2017 | 29121071 |
| treatment with nonsteroidal anti-inflammatory drugs fails to ameliorate pathology in cockatiels experimentally infected with parrot bornavirus-2. | parrot bornavirus is the etiological agent of parrot bornavirus syndrome, also referred to and comprising proventricular dilatation disease or pdd, macaw wasting disease, enteric ganglioneuritis and encephalitis, and avian ganglioneuritis. it has been suggested that nonsteroidal anti-inflammatory drugs may be able to ameliorate this disease. therefore, this study investigated the effects of two commonly used nonsteroidal anti-inflammatory drugs, celecoxib and meloxicam, on cockatiels experimenta ... | 2019 | 31819861 |
| recombinant modified vaccinia virus ankara (mva) vaccines efficiently protect cockatiels against parrot bornavirus infection and proventricular dilatation disease. | parrot bornaviruses (pabvs) are the causative agents of proventricular dilatation disease (pdd), a chronic and often fatal neurologic disorder in psittaciformes. the disease is widely distributed in private parrot collections and threatens breeding populations of endangered species. thus, immunoprophylaxis strategies are urgently needed. in previous studies we demonstrated a prime-boost vaccination regime using modified vaccinia virus ankara (mva) and newcastle disease virus (ndv) constructs exp ... | 2019 | 31817690 |
| distribution of viral antigen and inflammatory lesions in the central nervous system of cockatiels ( nymphicus hollandicus) experimentally infected with parrot bornavirus 2. | neurotropism is a striking characteristic of bornaviruses, including parrot bornavirus 2 (pabv-2). our study evaluated the distribution of inflammatory foci and viral nucleoprotein (n) antigen in the brain and spinal cord of 27 cockatiels ( nymphicus hollandicus) following experimental infection with pabv-2 by injection into the pectoral muscle. tissue samples were taken at 12 timepoints between 5 and 114 days post-inoculation (dpi). each experimental group had approximately 3 cockatiels per gro ... | 2019 | 30235986 |