cloning of the major capsid protein (mcp) of grouper iridovirus of taiwan (tgiv) and preliminary evaluation of a recombinant mcp vaccine against iridoviruses cause systemic diseases with high mortality in various species of wild and farm-raised fish, resulting in severe economic losses. in 1998, we isolated a new epizootic iridovirus in cultured grouper (epinephelus sp.) in taiwan, thus named as grouper iridovirus of taiwan (tgiv). we report here the cloning of tgiv major capsid protein (mcp). phylogenetic analysis of the iridoviral mcps confirmed the classification of tgiv into the megalocytivirus genus. recombinant tgiv mcp and gi ...201526633384
comparison of grouper infection with two different iridoviruses using transcriptome sequencing and multiple reference species selection.due to high-density aquafarming in taiwan, groupers are commonly infected with two different iridoviruses: megalocytivirus (grouper iridovirus of taiwan, tgiv) and ranavirus (grouper iridovirus, giv). iridoviral diseases cause mass mortality, and surviving fish retain these pathogens, which can then be horizontally transferred. these viruses have therefore become a major challenge for grouper aquaculture. in this study, comparisons of the biological responses of groupers to infection with these ...201728939532
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