| human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury. | many therapeutic interventions for spinal cord injury (sci) using neurotrophic factors have focused on reducing the area damaged by secondary, post-injury degeneration, to promote functional recovery. hepatocyte growth factor (hgf), which is a potent mitogen for mature hepatocytes and a mediator of the inflammatory responses to tissue injury, was recently highlighted as a potent neurotrophic factor in the central nervous system. we previously reported that introducing exogenous hgf into the inju ... | 2011 | 22140459 |
| fatal herpes simplex infection in a group of common marmosets (callithrix jacchus). | an outbreak of classical herpetic infection causing vesicoulcerative stomatitis in a family group (eight animals) of callithrix jacchus is described. in all eight infected animals, human herpesvirus 1 (hhv-1) was identified as the causative agent. this was confirmed by histologic, immunohistologic, and molecular biologic investigations, as well as by virus isolation. the clinical picture, the macroscopic appearance, and the histologic results indicated a herpes infection as the cause of mortalit ... | 2003 | 12824512 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| herpesvirus saimiri pathogenicity enhanced by thymidine kinase of herpes simplex virus. | herpesvirus saimiri can be used as an efficient gene expression vector for human t lymphocytes and thus may allow applications in experimental leukemia therapy. we constructed recombinant viruses for the functional expression of the thymidine kinase (tk) of herpes simplex virus type 1 (hsv) as a suicide gene. these viruses reliably allowed the targeted elimination of transduced nonpermissive human t cells in vitro after the administration of ganciclovir. to test the reliability of this function ... | 2000 | 11118367 |
| development of a novel non-human primate model for preclinical gene vector safety studies. determining the effects of intracerebral hsv-1 inoculation in the common marmoset: a comparative study. | the owl monkey (aotus trivirgatus) has served as the standard non-human primate model of herpes simplex virus-1 (hsv-1) infection because it is highly susceptible to hsv-1 encephalitis. owl monkeys, however, are expensive, difficult to obtain, and difficult to maintain in captivity, thus greatly hampering the efficiency of preclinical gene therapy trials for brain tumors using hsv-1-based vectors. we have therefore compared the susceptibility of the common marmoset (callithrix jacchus) with the ... | 2003 | 12858187 |
| herpes simplex virus type 1 infection in two pet marmosets in japan. | an 8-month-old common marmoset (callithrix jacchus) was presented with tic-like symptoms, and a 2-year-old pigmy marmoset (callithrix pygmaea) was presented with dyspnea and hypersalivation. both monkeys died within a few days, and necropsies were performed. histopathological examinations revealed ulcerative stomatitis with epithelial cell swelling and eosinophilic intranuclear inclusion bodies in the oral epithelium of both cases. in the central and peripheral nervous systems, neuronal cell deg ... | 2014 | 25649955 |