molecular identification and characterization of nonprimate hepaciviruses in equines.hepatitis c virus (hcv) is a positive-sense rna virus belonging to the genus hepacivirus, family flaviviridae. its genome has a length of 9.6 kb and encodes a single polyprotein flanked by two untranslated regions. hcv can cause liver cirrhosis and hepatocellular carcinoma, and approximately 2% of the world's population is chronically infected. the investigation of pathogenesis is complicated due to the lack of an animal model. the origin of this virus remains unclear, but in the last few years, ...201930361815
seroepidemiology of non-primate hepacivirus (nphv) in japanese native horses.non-primate hepacivirus (nphv) is recently identified as a closely related homologue of hepatitis c virus. the previous studies showed a high prevalence of nphv infection among japanese domestic horses originated from abroad. the historical distribution of nphv among horses in japan, therefore, is still unknown. in this study, seroepidemiological study of nphv was conducted using 335 sera from five breeds of japanese native horses. these horses are maintained as the pedigree and are reared apart ...201829187712
viraemic frequencies and seroprevalence of non-primate hepacivirus and equine pegiviruses in horses and other mammalian species.non-primate hepacivirus (nphv), equine pegivirus (epgv) and theiler's disease associated virus (tdav) are newly discovered members of two genera in the flaviviridae family, hepacivirus and pegivirus respectively, that include human hepatitis c virus (hcv) and human pegivirus (hpgv). to investigate their epidemiology, persistence and clinical features of infection, large cohorts of horses and other mammalian species were screened for nphv, epgv and tdav viraemia and for past exposure through sero ...201424814924
ligand-responsive rna mechanical switches.ligand-responsive rna mechanical switches represent a new class of simple switching modules that adopt well-defined ligand-free and bound conformational states, distinguishing them from metabolite-sensing riboswitches. initially discovered in the internal ribosome entry site (ires) of hepatitis c virus (hcv), these rna switch motifs were found in the genome of diverse other viruses. although large variations are seen in sequence and local secondary structure of the switches, their function in vi ...201526158858
epidemiological investigation and analysis of the ns5b gene and protein variability of non-primate hepacivirus in several horse cohorts in rio de janeiro state, brazil.among the hepacivirus species recently described, the non-primate hepacivirus/hepacivirus a found in horses and donkeys is closely related to the human hepatitis c virus (hcv). therefore, the equine is an attractive surrogate large animal model for the study of hcv therapy, pathogenesis and prophylaxis. despite global efforts, epidemiological and genetic studies have not elucidated the risk factors, virus distribution or genetic variability of the hepacivirus a, which are also important issues f ...201829413884
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