| eilat virus host range restriction is present at multiple levels of the virus life cycle. | most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates, including birds, rodents, equids, humans, and nonhuman primates. this ability of most alphaviruses to infect arthropods and vertebrates is essential for their maintenance in nature. recently, a new alphavirus, eilat virus (eilv), was described, and in contrast to all other mosquito-borne viruses, it is unable to replicate in vertebrate cell lines. investigations into the nature of its host ... | 2014 | 25392227 |
| eilat virus, a unique alphavirus with host range restricted to insects by rna replication. | most alphaviruses and many other arboviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, humans, and nonhuman primates. consequently, they can be propagated in most vertebrate and insect cell cultures. this ability of arboviruses to infect arthropods and vertebrates is usually essential for their maintenance in nature. however, several flaviviruses have recently been described that infect mosquitoes but not vertebrates ... | 2012 | 22908261 |
| utilization of an eilat virus-based chimera for serological detection of chikungunya infection. | in december of 2013, chikungunya virus (chikv), an alphavirus in the family togaviridae, was introduced to the island of saint martin in the caribbean, resulting in the first autochthonous cases reported in the americas. as of january 2015, local and imported chikv has been reported in 50 american countries with over 1.1 million suspected cases. chikv causes a severe arthralgic disease for which there are no approved vaccines or therapeutics. furthermore, the lack of a commercially available, se ... | 2015 | 26492074 |
| eilat virus induces both homologous and heterologous interference. | most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, and humans. occasionally, alphaviruses can spill over into the human population and cause disease characterized by debilitating arthralgia or fatal encephalitis. recently, a unique alphavirus, eilat virus (eilv), was described that readily infects mosquito but not vertebrate cell lines. here, we investigated the ability of eilv to induce superinfection exclu ... | 2015 | 26068885 |
| eilat virus displays a narrow mosquito vector range. | most alphaviruses are arthropod-borne and utilize mosquitoes as vectors for transmission to susceptible vertebrate hosts. this ability to infect both mosquitoes and vertebrates is essential for maintenance of most alphaviruses in nature. a recently characterized alphavirus, eilat virus (eilv), isolated from a pool of anopheles coustani s.i. is unable to replicate in vertebrate cell lines. the eilv host range restriction occurs at both attachment/entry as well as genomic rna replication levels. h ... | 2014 | 25515341 |
| a chikungunya fever vaccine utilizing an insect-specific virus platform. | traditionally, vaccine development involves tradeoffs between immunogenicity and safety. live-attenuated vaccines typically offer rapid and durable immunity but have reduced safety when compared to inactivated vaccines. in contrast, the inability of inactivated vaccines to replicate enhances safety at the expense of immunogenicity, often necessitating multiple doses and boosters. to overcome these tradeoffs, we developed the insect-specific alphavirus, eilat virus (eilv), as a vaccine platform. ... | 2017 | 27991917 |
| discovery of a novel alphavirus related to eilat virus. | most alphaviruses are transmitted by arthropods and infect vertebrate hosts. an exception is eilat virus (eilv), the only described alphavirus with a host range restricted to insects. we established a new generic reverse transcription pcr assay for alphaviruses and tested 8860 tropical mosquitoes. we detected a novel alphavirus, tentatively named taï forest alphavirus (talv), in culex decens mosquitoes collected in ivory coast. the full genome was sequenced, and closest similarity was found to e ... | 2017 | 28206905 |
| discovery of a novel alphavirus related to eilat virus. | most alphaviruses are transmitted by arthropods and infect vertebrate hosts. an exception is eilat virus (eilv), the only described alphavirus with a host range restricted to insects. we established a new generic reverse transcription pcr assay for alphaviruses and tested 8,860 tropical mosquitoes. we detected a novel alphavirus, tentatively named taï forest alphavirus (talv), in culex decens mosquitoes collected in côte d'ivoire. the full genome was sequenced and closest similarity was found to ... | 2016 | 28005523 |