| durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection. | human pegivirus (hpgv)-formerly known as gb virus c and hepatitis g virus-is a poorly characterized rna virus that infects about one-sixth of the global human population and is transmitted frequently in the blood supply. we create an animal model of hpgv infection by infecting macaque monkeys with a new simian pegivirus (spgv) discovered in wild baboons. using this model, we provide a high-resolution, longitudinal picture of spgv viremia where the dose, route, and timing of infection are known. ... | 2015 | 26378244 |
| discovery of a novel simian pegivirus in common marmosets (callithrix jacchus) with lymphocytic enterocolitis. | from 2010 to 2015, 73 common marmosets (callithrix jacchus) housed at the wisconsin national primate research center (wnprc) were diagnosed postmortem with lymphocytic enterocolitis. we used unbiased deep-sequencing to screen the blood of deceased enterocolitis-positive marmosets for viruses. in five out of eight common marmosets with lymphocytic enterocolitis, we discovered a novel pegivirus not present in ten matched, clinically normal controls. the novel virus, which we named southwest bike t ... | 2020 | 33007921 |
| local virus extinctions following a host population bottleneck. | a small number of african green monkeys (agms) were introduced into the caribbean from west africa in the 1600s. to determine the impact of this population bottleneck on the agm virome, we used metagenomics to compare the viral nucleic acids in the plasma of 43 wild agms from west africa (gambia) to those in 44 agms from the caribbean (st. kitts and nevis). three viruses were detected in the blood of gambian primates: simian immunodeficiency virus (sivagm; in 42% of animals), a novel simian pegi ... | 2015 | 26018153 |
| pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of hiv infection. | human pegivirus (hpgv) protects hiv+ people from hiv-associated disease, but the mechanism of this protective effect remains poorly understood. we sequentially infected cynomolgus macaques with simian pegivirus (spgv) and simian immunodeficiency virus (siv) to model hiv+hpgv co-infection. spgv had no effect on acute-phase siv pathogenesis-as measured by siv viral load, cd4+ t cell destruction, immune activation, or adaptive immune responses-suggesting that hpgv's protective effect is exerted pri ... | 2017 | 29073258 |