| identification of rodent homologs of hepatitis c virus and pegiviruses. | hepatitis c virus (hcv) and human pegivirus (hpgv or gb virus c) are globally distributed and infect 2 to 5% of the human population. the lack of tractable-animal models for these viruses, in particular for hcv, has hampered the study of infection, transmission, virulence, immunity, and pathogenesis. to address this challenge, we searched for homologous viruses in small mammals, including wild rodents. here we report the discovery of several new hepaciviruses (hcv-like viruses) and pegiviruses ( ... | 2013 | 23572554 |
| viraemic frequencies and seroprevalence of non-primate hepacivirus and equine pegiviruses in horses and other mammalian species. | non-primate hepacivirus (nphv), equine pegivirus (epgv) and theiler's disease associated virus (tdav) are newly discovered members of two genera in the flaviviridae family, hepacivirus and pegivirus respectively, that include human hepatitis c virus (hcv) and human pegivirus (hpgv). to investigate their epidemiology, persistence and clinical features of infection, large cohorts of horses and other mammalian species were screened for nphv, epgv and tdav viraemia and for past exposure through sero ... | 2014 | 24814924 |
| discovery and characterization of distinct simian pegiviruses in three wild african old world monkey species. | within the flaviviridae, the recently designated genus pegivirus has expanded greatly due to new discoveries in bats, horses, and rodents. here we report the discovery and characterization of three simian pegiviruses (spgv) that resemble human pegivirus (hpgv) and infect red colobus monkeys (procolobus tephrosceles), red-tailed guenons (cercopithecus ascanius) and an olive baboon (papio anubis). we have designated these viruses spgvkrc, spgvkrtg and spgvkbab, reflecting their host species' commo ... | 2014 | 24918769 |
| combination adenovirus and protein vaccines prevent infection or reduce viral burden after heterologous clade c simian-human immunodeficiency virus mucosal challenge. | hiv vaccine development is focused on designing immunogens and delivery methods that elicit protective immunity. we evaluated a combination of adenovirus (ad) vectors expressing hiv 1086.c (clade c) envelope glycoprotein (env), siv gag p55, and human pegivirus gbv-c e2 glycoprotein. we compared replicating simian (sad7) with nonreplicating human (ad4) adenovirus-vectored vaccines paired with recombinant proteins in a novel prime-boost regimen in rhesus macaques, with the goal of eliciting protec ... | 2018 | 29093095 |
| pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of hiv infection. | human pegivirus (hpgv) protects hiv+ people from hiv-associated disease, but the mechanism of this protective effect remains poorly understood. we sequentially infected cynomolgus macaques with simian pegivirus (spgv) and simian immunodeficiency virus (siv) to model hiv+hpgv co-infection. spgv had no effect on acute-phase siv pathogenesis-as measured by siv viral load, cd4+ t cell destruction, immune activation, or adaptive immune responses-suggesting that hpgv's protective effect is exerted pri ... | 2017 | 29073258 |
| genetic variability of porcine pegivirus in pigs from europe and china and insights into tissue tropism. | pegiviruses belong to the family flaviviridae and have been found in humans and other mammalian species. to date eleven different pegivirus species (pegivirus a-k) have been described. however, little is known about the tissue tropism and replication of pegiviruses. in 2016, a so far unknown porcine pegivirus (ppgv, pegivirus k) was described and persistent infection in the host, similar to human pegivirus, was reported. in this study, qrt-pcr, phylogenetic analyses and fluorescence in situ hybr ... | 2019 | 31160748 |