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cluster of zoonotic cutaneous leishmaniasis (leishmania major) in european travelers returning from turkmenistan.we report a cluster of cutaneous leishmaniasis due to leishmania major in four immunocompetent travelers returning from western turkmenistan and having atypical and/or multiple lesions. treatments with pentamidine or fluconazole were effective. physicians should be aware that some virulent strains of l major currently circulate in central asia.201624165385
[ankle and foot ulcerations in a diabetic patient revealing cutaneous leishmaniasis].cutaneous leishmaniasis is a parasitic disease that typically manifests as a typical crusted ulcer called the oriental sore. its localization on the lower limbs can be mistaken for a leg ulcer.201425201090
heterogeneity of molecular resistance patterns in antimony-resistant field isolates of leishmania species from the western mediterranean area.antimonials remain the first-line treatment for the various manifestations of leishmaniasis in most areas where the disease is endemic, and increasing cases of therapeutic failure associated with parasite resistance have been reported. in this study, we assessed the molecular status of 47 clinical isolates of leishmania causing visceral and cutaneous leishmaniasis from algeria, tunisia, and southern france. in total, we examined 14 genes that have been shown to exhibit significant variations in ...201424913173
infectious complications in polymyositis and dermatomyositis: a series of 279 patients.objectives:: to assess the prevalence and characteristics of severe pyogenic, nonpyogenic, and opportunistic infections in polymyositis and dermatomyositis (pm/dm) patients and to evaluate the predictive values for infections on clinical presentation and biochemical findings of pm/dm to detect patients at risk for such infections. methods:: the medical records of 279 consecutive pm/dm patients in 3 medical centers were reviewed. results:: one hundred four severe infections occurred in our patien ...201021047670
wr279,396, a third generation aminoglycoside ointment for the treatment of leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study.cutaneous leishmaniasis (cl) is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. topical treatment of cl offers a practical and safe option. accordingly, the treatment of cl with wr279,396, a formulation of paromomycin and gentamicin in a hydrophilic base, was investigated in a phase 2 clinical study in tunisia and france.200919415122
rapid identification of causative species in patients with old world leishmaniasis.conventional methods for the identification of species of leishmania parasite causing infections have limitations. by using a dna-based alternative, the present study tries to develop a new tool for this purpose. thirty-three patients living in marseilles (in the south of france) were suffering from visceral or cutaneous leishmaniasis. dna of the parasite in clinical samples (bone marrow, peripheral blood, or skin) from these patients were amplified by pcr and were directly sequenced. the sequen ...19979316906
[leishmania infantum nicolle, 1908, the agent of the autochthonous oriental sore. apropos of the biochemical identification of 2 strains isolated in the eastern pyrenees].two strains of parasites isolated from cases of oriental sore in the pyrénées-orientales were identified by electrophoretic analysis of eight isoenzymes (pgm, pgi, g-6-pdh, 6-pgdh, idh, mdh, me and got). both strains were identical with leishmania infantum nicolle, 1908, which normally causes visceral leishmaniasis. it is probable that, in the mediterranean region, some cutaneous lesions observed within the area of visceral leishmaniasis are caused by this species rather than by leishmania tropi ...19806780226
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