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leishmanicidal active withanolides from a pakistani medicinal plant, withania coagulans.in the course of screening for leishmanicidal constituents from asian and south american medicinal plants, a pakistani medicinal plant, withania coagulans, showed activity. we therefore studied the active components of the methanol extract of aerial parts of w. coagulans. from the ethyl acetate soluble fraction of the extract, four new withanolides (1-4) were isolated along with seven known withanolides (5-11). the new compounds were elucidated to be (14r,15r,17s,20s,22r)-14,15,17,20-tetrahydrox ...201222790824
efficacy of glucantime in the treatment of old world cutaneous leishmaniasis.leishmaniasis is a parasitic disease caused by protozoa of the genus leishmania. depending on the parasite species and host response, the disease presents itself in different clinical forms. the cutaneous form of the disease is most common in the old world. pentavalent antimonials in the form of an injection represent the most widely used therapy for all clinical forms of the disease. as a result of reports on the development of resistance from various parts of the world, we thought it pertinent ...200919570087
cycloartane triterpenoids from astragalus bicuspis.three new cycloartane glycosides have been isolated from astragalus bicuspis. they were identified as 6alpha-hydroxy-3-o-beta-xylopyranosyloxy-24,25,26,27-tetranor-9,19-cyclolanosta-16,23-lactone (1), 6alpha-hydroxy-23-methoxy-16beta,23(r)-epoxy-24,25,26,27-tetranor-9,19-cyclolanosta-3-o-beta-xyloside (2), and 23(r),24(s),25(r),26(s)-16beta/23,23/26,24/25-triepoxy-6alpha,26-dihydroxy-9,19-cyclolanosta-3-o-beta-xyloside (3), on the basis of their spectroscopic data. two known cycloartane derivati ...200818771242
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