| different susceptibilities of leishmania spp. promastigotes to the annona muricata acetogenins annonacinone and corossolone, and the platymiscium floribundum coumarin scoparone. | leishmaniasis is a zoonotic disease that can manifest itself in visceral and cutaneous form. the aim of this study was to search for new leishmanicidal compounds. preliminarily, artemia salina assay was applied to compounds from two plants found in northeastern brazil, platymiscium floribundum and annona muricata. then these compounds were tested against three leishmania species (leishmania donovani, leishmania mexicana and leishmania major). a screening assay using luciferase-expressing promast ... | 2013 | 23232251 |
| wound healing genes and susceptibility to cutaneous leishmaniasis in brazil. | leishmania braziliensis causes cutaneous (cl) and mucosal (ml) leishmaniasis. in the mouse, fli1 was identified as a gene influencing enhanced wound healing and resistance to cl caused by leishmania major. polymorphism at fli1 is associated with cl caused by l. braziliensis in humans, with an inverse association observed for ml disease. here we extend the analysis to look at other wound healing genes, including ctgf, tgfb1, tgfbr1/2, smads 2/3/4/7 and flii, all functionally linked along with fli ... | 2012 | 22554650 |
| leishmania sp. isolated from human cases of cutaneous leishmaniasis in brazil characterized as leishmania major-like. | the identification and characterization of leishmania are relevant to diagnosis, treatment, eco-epidemiology studies, prophylactic measures and control of the disease. two strains of leishmania (mhom/br/1971/bh49 and mhom/br/1971/bh121), isolated from human cutaneous leishmaniasis, were studied using biological and molecular characteristics, in comparison with who reference strains. these studies are important because both strains were incorporated in a vaccine against american cutaneous leishma ... | 2009 | 19660430 |
| new sesquiterpene lactones from elephantopus mollis and their leishmanicidal activities. | the leishmanicidal compounds isolated from whole plants of elephantopus mollis h.b.k. were identified as follows. three new sesquiterpenoid lactones, 2,5-epoxy-2beta-hydroxy-8alpha-(2-methylpropenoyloxy)-4(15),10(14),11(13)-germacratrien-12,6alpha-olide, (4betah)-8alpha-(2-methylpropenoyloxy)-2-oxo-1(5),10(14), 11(13)-guaiatrien-12,6alpha-olide and (4betah)-5alpha-hydroxy-8alpha-(2-methylpropenoyloxy)-1(10),11(13)-guaiadiene-12,6alpha-olide, were isolated from peruvian and brazilian collections ... | 2001 | 11582544 |
| brazilian leishmania stocks phenotypically similar to leishmania major. | screening by enzyme electrophoresis of isolates of new world leishmania from different geographic areas revealed a number of stocks with enzyme profiles different from those produced by reference strains of described subspecies of l. mexicana, l. braziliensis, and l. donovani. analysis by six enzymes (aspartate aminotransferase; alanine aminotransferase; malate dehydrogenase; glucose-6-phosphate dehydrogenase; phosphoglucomutase; and glucose-phosphate isomerase) showed that these stocks have ide ... | 1985 | 3834794 |