anti-protozoal activity of aporphine and protoberberine alkaloids from annickia kummeriae (engl. & diels) setten & maas (annonaceae).malaria, trypanosomiasis and leishmaniasis have an overwhelming impact in the poorest countries in the world due to their prevalence, virulence and drug resistance ability. currently, there is inadequate armory of drugs for the treatment of malaria, trypanosomiasis and leishmaniasis. this underscores the continuing need for the discovery and development of new anti-protozoal drugs. consequently, there is an urgent need for research aimed at the discovery and development of new effective and safe ...201323445637
antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected tanzanian medicinal plants.the antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven tanzanian medicinal plants: annickia (enantia) kummeriae (annonaceae), artemisia annua (asteraceae), pseudospondias microcarpa (anacardiaceae), drypetes natalensis (euphorbiaceae), acridocarpus chloropterus (malpighiaceae), maytenus senegalensis (celastraceae) and neurautanenia mitis (papilonaceae), were evaluated in vitro against plasmodium falciparum k1, trypanosoma brucei rhodesiense s ...200920734703
antiprotozoal polyacetylenes from the tanzanian medicinal plant cussonia zimmermannii.from the petroleum ether extract of the root bark of cussonia zimmermannii four polyacetylenes, 1- 4, were isolated, three of which ( 1- 3) were active against trypanosoma brucei rhodesiense, trypanosoma cruzi, plasmodium falciparum, and leishmania donovani.200717922552
ancistrotanzanine a, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species ancistrocladus tanzaniensis.the first phytochemical investigation of the recently discovered east african liana ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids, ancistrotanzanines a (5) and b (6), and the known compound ancistrotectoriline a (7). ancistrotazanine a (5) represents a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions, while 6 and 7 are 5,8'-coupled. the structures of the compound ...200314510589
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