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a new antimalarial quassinoid from simaba orinocensis.a new antimalarial quassinoid, namely, orinocinolide (1), was isolated from the root bark of simaba orinocensis, together with the previously reported simalikalactone d (2). the structure of 1 was determined primarily from 1d and 2d nmr analysis, as well as by chemical derivatization. compound 1 was found to be as equally potent as 2 against plasmodium falciparum clones d6 and w2 (ic(50) 3.27 and 8.53 ng/ml vs 3.0 and 3.67 ng/ml, respectively), but was 4- and 28-fold less toxic than 2 against ve ...200415165136
multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant leishmania braziliensis isolates from peru.in order to understand the epidemiological dynamics of antimonial (sb(v)) resistance in zoonotic tegumentary leishmaniasis and its link with treatment outcome, we analyzed the population structure of 24 peruvian leishmania braziliensis clinical isolates with known in vitro antimony susceptibility and clinical phenotype by multilocus microsatellite typing (14 microsatellite loci). the genetic variability in the peruvian isolates was high and the multilocus genotypes were strongly differentiated f ...201121871584
regulation of leishmania populations within the host. v. resistance to l.donovani in wild mice.samples of wild mus musculus from two populations in areas endemic for leishmaniasis and from seven populations in non-endemic areas were found to be uniformly resistant when tested for their early response to leishmania donovani infection. males from one endemic and one non-endemic population were crossed to females from two inbred strains of mice carrying the susceptible allele for the innate resistance gene, lsh, on different genetic backgrounds. bimodality of liver parasite counts and a clos ...19836854699
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