anti-leishmanial, anti-inflammatory and antimicrobial activities of phenolic derivatives from tibouchina paratropica.a new phenolic derivative, 2,8-dihydroxy-7h-furo[2,3-f]chromen-7-one (1), together with isoquercitrin (2), was isolated from the aerial parts of tibouchina paratropica. compound structures were elucidated by spectroscopic methods. both compounds show antimicrobial activity towards a panel of bacterial and fungal pathogens, and compound 1 displayed potent anti-parasitic activity against leishmania donovani (ic50  = 0.809 µg/ml). in addition, an 85% reduction in the secretion of the pro-inflammato ...201525417600
a mr 90 000 surface polypeptide of trypanosoma cruzi as a candidate for a chagas' disease diagnostic antigen.trypanosoma cruzi (peru strain) trypomastigotes and epimastigotes were biosynthetically labeled with [35s]methionine, and the proteins were analyzed by two dimensional polyacrylamide gel electrophoresis (2d-page). 2d-page analysis of the trypomastigotes showed a complex array of polypeptides with distinct clusters at mr 88 000-92 000, isoelectric point (pi) 5.6-6.0, and mr 72 000-76 000, pi 5.6-5.8. 2d-page analysis of the epimastigotes did not show the cluster of polypeptides at mr 90 000. when ...19853932849
a novel molecular test to diagnose canine visceral leishmaniasis at the point of care.dogs are the principal reservoir hosts of zoonotic visceral leishmaniasis (vl) but current serological methods are not sensitive enough to detect all subclinically infected animals, which is crucial to vl control programs. polymerase chain reaction (pcr) methods have greater sensitivity but require expensive equipment and trained personnel, impairing its implementation in endemic areas. we developed a diagnostic test that uses isothermal recombinase polymerase amplification (rpa) to detect leish ...201526240156
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