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lower low-density lipoprotein cholesterol levels are associated with severe dengue outcome.dengue virus (denv) is a flavivirus of worldwide importance, with approximately 4 billion people across 128 countries at risk of infection, and up to 390 million infections and 96 million clinically apparent cases estimated annually. previous in vitro studies have shown that lipids and lipoproteins play a role in modifying virus infectivity. however, the relationship between development of severe dengue and total cholesterol, high-density lipoprotein cholesterol (hdl-c), and low-density lipoprot ...201526334914
increased replicative fitness of a dengue virus 2 clade in native mosquitoes: potential contribution to a clade replacement event in nicaragua.the four dengue virus (denv) serotypes (denv serotype 1 [denv-1] to denv-4) are transmitted by aedes aegypti and a. albopictus mosquitoes, causing up to 390 million denv infections worldwide each year. we previously reported a clade replacement of the denv-2 asian-american genotype ni-1 clade by the ni-2b clade in managua, nicaragua. here, we describe our studies of the replicative ability of ni-1 and ni-2b viruses in an a. aegypti cell line (aag2) and a. aegypti mosquitoes reared from eggs coll ...201425187539
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