genotypic variation in coxsackievirus b5 isolates from three different outbreaks in the united states.genomic sequences in vp1/2a and 5'-non-coding region of 10 isolates of coxsackievirus b5 from three outbreaks were compared with published sequences of another coxsackievirus b5, swine vesicular disease virus, coxsackievirus b1, coxsackievirus b3, and coxsackievirus b4. isolates of coxsackievirus b5 from the same outbreak showed close relations, not exceeding 7.2% in nucleotide differences. differences were greater between isolates from different outbreaks, varying between 8.4 and 16%. we have a ...19958578854
an attenuating mutation in the 2a protease of swine vesicular disease virus, a picornavirus, regulates cap- and internal ribosome entry site-dependent protein synthesis.virulent and avirulent strains of swine vesicular disease virus (svdv), a picornavirus, have been characterized previously. the major determinants for attenuation have been mapped to specific residues in the 1d-2a-coding region. the properties of the 2a proteases from the virulent and avirulent strains of svdv have now been examined. both proteases efficiently cleaved the 1d/2a junction in vitro and in vivo. however, the 2a protease of the avirulent strain of svdv was much less effective than th ...200111602706
specificity of the coxsackievirus b4 vp4 capsid protein investigated in silico.the enterovirus genus encompasses several species and various serotypes, like coxsackievirus-b1 (cv-b1) to cv-b6, and many variants. the role of these viruses, especially cv-b4, in the pathogenesis of type 1 diabetes is strongly suspected. it has been reported that antibodies directed towards the region of amino acids 11-30 of the vp4 capsid protein enhance the infection of human peripheral blood mononuclear cells with cv-b4. in order to predict the inter- and intra-serotype specificity of the r ...201121878192
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