| experimental cryptococcosis: dissemination of cryptococcus neoformans and dermotropism in guinea-pigs. | | 1986 | 3547123 |
| morphine enhances complement receptor-mediated phagocytosis of cryptococcus neoformans by human microglia. | recent studies have shown that opiates modulate the function of microglia, the resident macrophages of the brain. in this study, the effect of morphine on phagocytosis by human fetal microglial cells of the opportunistic fungus cryptococcus neoformans was studied. contrary to earlier findings with swine microglia, opsonization was required for the phagocytosis of c. neoformans by human microglia. moreover, morphine (10(-8)m) was shown to augment uptake of opsonized c. neoformans by over 50%. thi ... | 1998 | 9614931 |
| [australian fungus makes canada unsafe]. | | 2002 | 12389579 |
| effect of heat-treated amphotericin b on renal and fungal cytotoxicity. | the purpose of this investigation was to determine the cytotoxicity of amphotericin b (amb; trade name fungizone [fz]) following the administration of fz and a heat-treated form of fz (hfz) to llc-pk(1) pig kidney cells and cryptococcus neoformans var. gattii cells. hfz was significantly less toxic to kidney cells than fz at all concentrations tested. for both fz and hfz, the concentration range which resulted in a 50% reduction of the growth of fungal cells was 0.125 to 1 mg/ml. these findings ... | 2004 | 14693561 |
| in vitro antifungal activities of inhibitors of phospholipases from the fungal pathogen cryptococcus neoformans. | secreted phospholipase b is a proven virulence factor for the pathogenic fungus cryptococcus neoformans and exhibits three phospholipase activities in the one protein. these are phospholipase b (plb), lysophospholipase (lpl), and lysophospholipase transacylase (lpta). our aim was to investigate the feasibility of using this enzyme as a target for antifungal therapy. we determined in c. neoformans var. grubii strain h99 that 82% of plb activity was secreted but that 64% of lpl activity and 70% of ... | 2004 | 15105106 |
| the first isolation of cryptococcus neoformans from eucalyptus trees in south aegean and mediterranean regions of anatolia in turkey despite taurus mountains alkalinity. | eucalyptus trees are widespread in subtropical parts of turkey that have alkaline environments due to the soil structure of taurus mountains. in this study, the existence of cryptococcus neoformans in eucalyptus trees in the south aegean and mediterranean regions of anatolia, turkey, was screened between march 1998 and september 2002. only one strain of cryptococcus neoformans var. grubii (serotype a) was isolated from 1175 eucalyptus samples including debris and flowers in culture by guizotia a ... | 2004 | 15487319 |
| structural and functional characterization of the porcine proline-rich antifungal peptide sp-b isolated from salivary gland granules. | a 1905-da cationic proline-rich peptide, named sp-b, was recently isolated by our group as the main component of salivary gland granules, and its primary sequence fully characterized by means of automated edman sequencing and lc-ms/ms tools. in the present study sp-b is shown to possess antifungal activity when challenged with strains of cryptococcus neoformans, candida albicans and aspergillus fumigatus, while only negligible antibacterial activity was detected. furthermore, sp-b was found to b ... | 2008 | 17883246 |
| synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes. | a series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5'-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with mics in the range of 1.4-2.7 microm against reference strains of both cryptococcus neoformans and candida albicans. | 2009 | 19665385 |
| virulence in cryptococcus species. | cryptococcus neoformans and cryptococcus gattii are the cause of life-threatening meningoencephalitis in immunocompromised and immunocompetent individuals respectively. the increasing incidence of cryptococcal infection as a result of the aids epidemic, the recent emergence of a hypervirulent cryptococcal strain in canada and the fact that mortality from cryptococcal disease remains high have stimulated intensive research into this organism. here we outline recent advances in our understanding o ... | 2009 | 19245939 |
| synthesis, antifungal activity, and structure-activity relationships of coruscanone a analogues. | coruscanone a, a plant-derived cyclopentenedione derivative, showed potent in vitro antifungal activity against candida albicans and cryptococcus neoformans comparable to amphotericin b and fluconazole. a series of analogues have been synthesized by modification of the cyclopentenedione ring, the enolic methoxy functionality, and the side chain styryl moiety of this natural product lead. a structurally close 1,4-benzoquinone analogue was also prepared. all the compounds were examined for their i ... | 2006 | 17181171 |
| inhibition of swine microglial cell phagocytosis of cryptococcus neoformans by femtomolar concentrations of morphine. | microglia are important immune effector cells within the brain. the phagocytosis of nonopsonized cryptococcus neoformans by swine microglia was used as an in vitro model for studies on cellular mechanisms of opiate-mediated immunomodulation in the brain. morphine inhibited potently (ic50 approximately 10(-16) m) the phagocytosis of c. neoformans by primary cultures of neonatal pig microglia. the mu opioid agonist tyr-d-ala-gly-n-me-phe-gly-ol (damgo) also suppressed phagocytosis but with a much ... | 1997 | 9113103 |
| a potent specific inhibitor of 6-phosphogluconate dehydrogenase of cryptococcus neoformans and of certain other fungal enzymes. | a particular lot of the zwitterionic buffer, 2(n-morpholino) ethane sulfonic acid (mes), contained a contaminant that inhibited a number of fungal nadp-dependent dehydrogenases. enzymes that were particularly sensitive include 6-phosphogluconate dehydrogenases from cryptococcus neoformans and schizophyllum commune and glucose-6-phosphate dehydrogenase from schizophyllum commune. a number of nadp-dependent dehydrogenases of animal origin were tested and all were completely insensitive to inhibiti ... | 1993 | 8302365 |
| oxiconazole, a new imidazole derivative. evaluation of antifungal activity in vitro and in vivo. | the new imidazole derivative z-[2,4-dichloro-2-imidazol-1-yl)acetophenone]-o-(2,4-dichlorobenzyl)-oxime nitrate (oxiconazole, ro 13-8996) is characterized by a broad fungistatic spectrum against the agents of human mycoses in vitro. in addition, fungicidal activity of various degree was found in selected species (aspergillus fumigatus, cryptococcus neoformans, candida albicans and trichophyton mentagrophytes). synthesis of dna was inhibited by subinhibitory concentrations of oxiconazole in paral ... | 1982 | 7037014 |
| in vitro reactivity of natural killer (nk) cells against cryptococcus neoformans. | | 1982 | 6120974 |
| [synthesis and antifungal activity of butenafine hydrochloride (kp-363), a new benzylamine antifungal agent]. | in screening of new antifungal agents, bis(naphthalenemethyl)amines were found to have more potent antifungal activity than clotrimazole. studies on their structure-activity relationships indicated that benzylamines had potent antifungal activity. among them, butenafine hydrochloride (n-p-tert-butylbenzyl-n-methyl-1-naphthalenemethylamine hydrochloride, kp-363) has proved to show the strongest activity. it exhibits a wide spectrum activity in vitro against particularly dermatophytes (87 strains; ... | 1991 | 2056447 |
| fungicidal activity of five cathelicidin peptides against clinically isolated yeasts. | to investigate the in vitro antifungal activity of the structurally different cathelicidin peptides smap-29, bmap-27, bmap-28, protegrin-1 (pg-1) and indolicidin. | 2006 | 17023499 |
| phagocytosis of nonopsonized cryptococcus neoformans by swine microglia involves cd14 receptors. | the interaction of the opportunistic fungus cryptococcus neoformans with swine microglia was studied in vitro in the presence and absence of anti-cd14 monoclonal antibodies. in the absence of anti-cd14 antibodies, 36% of microglia had phagocytized nonopsonized, encapsulated cryptococci after 2 hr incubation (effector-to-target ratio, 1:50). preincubation of microglia with anti-cd14 antibodies resulted in a 63% reduction of phagocytosis. these findings suggest that cd14 receptors facilitate uptak ... | 1997 | 9245554 |
| in vitro antifungal spectrum of itraconazole and treatment of systemic mycoses with old and new antimycotic agents. | itraconazole is a lipophilic triazole with potent in vitro activity. it is also effective after topical, oral and parenteral administration. the antifungal activity of itraconazole has been evaluated against more than 6,500 different strains, belonging to more than 260 fungal species, using the serial decimal dilution test in fluid broth medium (brain-heart infusion broth). candida spp., torulopsis spp., cryptococcus neoformans, pityrosporum spp. (dixon broth), various other yeasts, dermatophyte ... | 1992 | 1319313 |