| increased replicative fitness of a dengue virus 2 clade in native mosquitoes: potential contribution to a clade replacement event in nicaragua. | the four dengue virus (denv) serotypes (denv serotype 1 [denv-1] to denv-4) are transmitted by aedes aegypti and a. albopictus mosquitoes, causing up to 390 million denv infections worldwide each year. we previously reported a clade replacement of the denv-2 asian-american genotype ni-1 clade by the ni-2b clade in managua, nicaragua. here, we describe our studies of the replicative ability of ni-1 and ni-2b viruses in an a. aegypti cell line (aag2) and a. aegypti mosquitoes reared from eggs coll ... | 2014 | 25187539 |
| early clinical features of dengue virus infection in nicaraguan children: a longitudinal analysis. | tens of millions of dengue cases and approximately 500,000 life-threatening complications occur annually. new tools are needed to distinguish dengue from other febrile illnesses. in addition, the natural history of pediatric dengue early in illness in a community-based setting has not been well-defined. | 2012 | 22413033 |
| evidence based community mobilization for dengue prevention in nicaragua and mexico (camino verde, the green way): cluster randomized controlled trial. | to test whether community mobilization adds effectiveness to conventional dengue control. | 2015 | 26156323 |
| evaluation of the diagnostic utility of the traditional and revised who dengue case definitions. | dengue, a mosquito-borne viral illness, is a major public health problem worldwide, and its incidence continues to increase. in 2009, the world health organization published guidelines that included a revision of the dengue case definition. compared to the traditional definition, the revised case definition relies more on signs than on symptoms, making it more applicable to young children. we evaluated the diagnostic utility of both case definitions in two studies of pediatric dengue in managua, ... | 2013 | 23991237 |
| lower low-density lipoprotein cholesterol levels are associated with severe dengue outcome. | dengue virus (denv) is a flavivirus of worldwide importance, with approximately 4 billion people across 128 countries at risk of infection, and up to 390 million infections and 96 million clinically apparent cases estimated annually. previous in vitro studies have shown that lipids and lipoproteins play a role in modifying virus infectivity. however, the relationship between development of severe dengue and total cholesterol, high-density lipoprotein cholesterol (hdl-c), and low-density lipoprot ... | 2015 | 26334914 |