| zika virus outbreak in rio de janeiro, brazil: clinical characterization, epidemiological and virological aspects. | in 2015, brazil was faced with the cocirculation of three arboviruses of major public health importance. the emergence of zika virus (zikv) presents new challenges to both clinicians and public health authorities. overlapping clinical features between diseases caused by zikv, dengue (denv) and chikungunya (chikv) and the lack of validated serological assays for zikv make accurate diagnosis difficult. | 2016 | 27070912 |
| culex quinquefasciatus from rio de janeiro is not competent to transmit the local zika virus. | the americas have suffered a dramatic epidemic of zika since may in 2015, when zika virus (zikv) was first detected in brazil. mosquitoes belonging to subgenus stegomyia of aedes, particularly aedes aegypti, are considered the primary vectors of zikv. however, the rapid spread of the virus across the continent raised several concerns about the transmission dynamics, especially about potential mosquito vectors. the purpose of this work was to assess the vector competence of the house mosquito cul ... | 2016 | 27598421 |
| isolation of infective zika virus from urine and saliva of patients in brazil. | zika virus (zikv) is an emergent threat provoking a worldwide explosive outbreak. since january 2015, 41 countries reported autochthonous cases. in brazil, an increase in guillain-barré syndrome and microcephaly cases was linked to zikv infections. a recent report describing low experimental transmission efficiency of its main putative vector, ae. aegypti, in conjunction with apparent sexual transmission notifications, prompted the investigation of other potential sources of viral dissemination. ... | 2016 | 27341420 |
| clinical manifestations of zika virus infection, rio de janeiro, brazil, 2015. | | 2016 | 27070847 |
| zika is not a reason for missing the olympic games in rio de janeiro: response to the open letter of dr attaran and colleagues to dr margaret chan, director - general, who, on the zika threat to the olympic and paralympic games. | attaran and colleagues in an open letter to who expressed their concern about the upcoming olympic and paralympic games in rio de janeiro and the threat posed by the zika epidemic (attaran 2016). we agree that zika virus is of great public health concern and much remains to be known about this disease. care should be taken to reduce the risk of infection, especially to pregnant women. however, we argue that this is not sufficient reason for changing the original plans for the games, in particula ... | 0 | 27304097 |
| first detection of natural infection of aedes aegypti with zika virus in brazil and throughout south america. | zika virus (zikv) has caused a major epidemic in brazil and several other american countries. zikv is an arbovirus whose natural vectors during epidemics have been poorly determined. in this study, 1,683 mosquitoes collected in the vicinity of zikv suspected cases in rio de janeiro, brazil, from june 2015 to may 2016 were screened for natural infection by using molecular methods. three pools of aedes aegypti were found with the zikv genome, one of which had only one male. this finding supports t ... | 2016 | 27706382 |
| zika virus infection in pregnant women in rio de janeiro. | background zika virus (zikv) has been linked to central nervous system malformations in fetuses. to characterize the spectrum of zikv disease in pregnant women and infants, we followed patients in rio de janeiro to describe clinical manifestations in mothers and repercussions of acute zikv infection in infants. methods we enrolled pregnant women in whom a rash had developed within the previous 5 days and tested blood and urine specimens for zikv by reverse-transcriptase-polymerase-chain-reaction ... | 2016 | 26943629 |
| first detection of autochthonous zika virus transmission in a hiv-infected patient in rio de janeiro, brazil. | since may 2015, brazil's ministry of health has reported autochthonous transmission of zika virus (zikv) in some states of the country. simultaneous circulation of dengue, chikungunya and zikv in the country hinder both the diagnosis and the therapeutic approach of patients seeking care with acute febrile illnesses especially in patients with comorbidities. the association between hiv infection and endemic diseases has been described especially in tropical regions with varying levels of complica ... | 2016 | 26615388 |
| zika in rio de janeiro: assessment of basic reproduction number and comparison with dengue outbreaks. | zika virus infection was declared a public health emergency of international concern in february 2016 in response to the outbreak in brazil and its suspected link with congenital anomalies. in this study, we use notification data and disease natural history parameters to estimate the basic reproduction number (r 0) of zika in rio de janeiro, brazil. we also obtain estimates of r 0 of dengue from time series of dengue cases in the outbreaks registered in 2002 and 2012 in the city, when denv-3 and ... | 2017 | 28240195 |
| trends of the microcephaly and zika virus outbreak in brazil, january-july 2016. | in the last two months, there have been indications that the zika virus epidemic is on the decline in brazil. we reviewed the surveillance data published by the brazilian ministry of health to assess trends of microcephaly and neurological abnormalities suggestive of congenital infection, as well as zika virus disease in brazil as a whole and its various regions. from november 2015 to july 2016, 8301 cases of microcephaly were reported in brazil, mainly in the northeast region. the number of new ... | 2017 | 27702683 |
| [zika virus - impact on the 2016 olympic games in rio de janeiro]. | there is an ongoing discussion in the media about the zika virus and the question of whether or not athletes and visitors will be at risk of an infection during the olympic games in rio de janeiro in 2016. according to an assessment published on 31 may 2016 by the ioc and the who, participants and visitors have no reason to panic. however, increasing public pressure has caused the who to re-evaluate the current situation, and further recommendations will likely be given before the olympic games ... | 2016 | 27490354 |
| the olympically mismeasured risk of zika virus in rio de janeiro. | | 2016 | 27480044 |
| the olympically mismeasured risk of zika virus in rio de janeiro - authors' reply. | | 2016 | 27480043 |
| projected zika virus importation and subsequent ongoing transmission after travel to the 2016 olympic and paralympic games - country-specific assessment, july 2016. | zika virus belongs to the genus flavivirus of the family flaviviridae; it is transmitted to humans primarily through the bite of an infected aedes species mosquito (e.g., ae. aegypti and ae. albopictus) (1). zika virus has been identified as a cause of congenital microcephaly and other serious brain defects (2). as of june 30, 2016, cdc had issued travel notices for 49 countries and u.s. territories across much of the western hemisphere (3), including brazil, where the 2016 olympic and paralympi ... | 2016 | 27442184 |
| update on zika virus: considerations for the traveling athlete. | as public health experts work to contain the outbreak of zika virus in south america and minimize the devastating prenatal complications, the international sports community prepares for the 2016 summer olympic and paralympic games in rio de janeiro, brazil. athletes have publicly expressed concern regarding the health risks of competition in zika-endemic areas.(33) ensuring the safety of the athletes during training and competition is the primary role of the team physician. special consideration ... | 2016 | 27436751 |
| potential exposure to zika virus for foreign tourists during the 2016 carnival and olympic games in rio de janeiro, brazil. | | 2016 | 27040593 |
| rapid spread of zika virus in the americas--implications for public health preparedness for mass gatherings at the 2016 brazil olympic games. | mass gatherings at major international sporting events put millions of international travelers and local host-country residents at risk of acquiring infectious diseases, including locally endemic infectious diseases. the mosquito-borne zika virus (zikv) has recently aroused global attention due to its rapid spread since its first detection in may 2015 in brazil to 22 other countries and other territories in the americas. the zikv outbreak in brazil, has also been associated with a significant ri ... | 2016 | 26854199 |
| maternal zika virus disease severity, virus load, prior dengue antibodies and their relationship to birth outcomes. | congenital zika virus (zikv) syndrome is a newly identified condition resulting from infection during pregnancy. we analyzed outcome data from a mother-infant cohort in rio de janeiro in order to assess whether clinical severity of maternal zikv infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. | 2017 | 28535184 |
| on the origin and timing of zika virus introduction in brazil. | the timing and origin of zika virus (zikv) introduction in brazil has been the subject of controversy. initially, it was assumed that the virus was introduced during the fifa world cup in june-july 2014. then, it was speculated that zikv may have been introduced by athletes from french polynesia (fp) who competed in a canoe race in rio de janeiro in august 2014. we attempted to apply mathematical models to determine the most likely time window of zikv introduction in brazil. given that the timin ... | 2017 | 28675351 |
| early evidence for zika virus circulation among aedes aegypti mosquitoes, rio de janeiro, brazil. | during 2014-2016, we conducted mosquito-based zika virus surveillance in rio de janeiro, brazil. results suggest that zika virus was probably introduced into the area during may-november 2013 via multiple in-country sources. furthermore, our results strengthen the hypothesis that zika virus in the americas originated in brazil during october 2012-may 2013. | 2017 | 28628464 |
| zika virus screening among spanish team members after 2016 rio de janeiro, brazil, olympic games. | we evaluated the risk for the spanish olympic team acquiring zika virus in rio de janeiro, brazil, during 2016. we recruited 117 team members, and all tested negative for zika virus. lack of cases in this cohort supports the minimum risk estimates made before the games. | 2017 | 28628450 |
| zika virus infection associated with congenital birth defects in a hiv-infected pregnant woman. | we describe a case of zika virus infection acquired during the first trimester in a hiv-infected pregnant woman that led to multiple fetal malformations and fetal demise in rio de janeiro, brazil. | 2017 | 28403053 |
| behavioral, climatic, and environmental risk factors for zika and chikungunya virus infections in rio de janeiro, brazil, 2015-16. | the burden of arboviruses in the americas is high and may result in long-term sequelae with infants disabled by zika virus infection (zikv) and arthritis caused by infection with chikungunya virus (chikv). we aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. we screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of rio de ... | 2017 | 29145452 |
| detection of zika virus in april 2013 patient samples, rio de janeiro, brazil. | we tested 210 dengue virus‒negative samples collected from febrile patients during a dengue virus type 4 outbreak in rio de janeiro in april 2013 and found 3 samples positive for zika virus. our findings support previously published entomological data suggesting zika virus was introduced into brazil during october 2012-may 2013. | 2017 | 28953451 |
| the spectrum of neurological disease associated with zika and chikungunya viruses in adults in rio de janeiro, brazil: a case series. | during 2015-16 brazil experienced the largest epidemic of zika virus ever reported. this arthropod-borne virus (arbovirus) has been linked to guillain-barré syndrome (gbs) in adults but other neurological associations are uncertain. chikungunya virus has caused outbreaks in brazil since 2014 but associated neurological disease has rarely been reported here. we investigated adults with acute neurological disorders for zika, chikungunya and dengue, another arbovirus circulating in brazil. | 2018 | 29432457 |
| autochthonous transmission of east/central/south african genotype chikungunya virus, brazil. | we isolated east/central/south african genotype chikungunya virus during the 2016 epidemic in rio de janeiro, brazil. genome sequencing revealed unique mutations in the nonstructural protein 4 (nsp4-a481d) and envelope protein 1 (e1-k211t). moreover, all brazil east/central/south isolates shared the exclusive mutations e1-m407l and e2-a103t. | 2017 | 28930027 |