| distribution of three arbovirus antibodies among monkeys (macaca fascicularis) in the philippines. | serum samples from 54 monkeys were collected from healthy individuals in a monkey farm in luzon island, philippines, in 1999, and examined by igm-capture elisa and indirect igg elisa for the presence of dengue (den), japanese encephalitis (je) and chikungunya (chik) viruses. the positive rates for igm elisa were 3.7, 35.2 and 14.8% against den, je and chik, respectively. higher positive rates were obtained when indirect igg elisa was used: 100% against flaviviruses (je or den) and 59.3% against ... | 2003 | 12823631 |
| chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. | chikungunya virus (chikv) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. the recent emergence or reemergence of chikv in the indian ocean islands and india has stressed the need to better understand the pathogenesis of this disease. previous chikv disease models have used young or immunodeficient mice, but these do not recapitulate human disease patterns and are unsuitable for testing immune-based therapies. herein, w ... | 2010 | 20179353 |
| nonhuman primate models of chikungunya virus infection and disease (chikv nhp model). | chikungunya virus (chikv) is a positive-sense rna virus transmitted by aedes mosquitoes. chikv is a reemerging alphavirus that causes acute febrile illness and severe and debilitating polyarthralgia of the peripheral joints. huge epidemics and the rapid spread of chikv seen in india and the indian ocean region established chikv as a global health concern. this concern was further solidified by the recent incursion of the virus into the western hemisphere, a region without pre-existing immunity. ... | 2015 | 26389957 |
| infectious chikungunya virus in the saliva of mice, monkeys and humans. | chikungunya virus (chikv) is a reemerging, ordinarily mosquito-transmitted, alphavirus that occasionally produces hemorrhagic manifestations, such as nose bleed and bleeding gums, in human patients. interferon response factor 3 and 7 deficient (irf3/7-/-) mice, which are deficient for interferon α/β responses, reliably develop hemorrhagic manifestations after chikv infection. here we show that infectious virus was present in the oral cavity of chikv infected irf3/7-/- mice, likely due to hemorrh ... | 2015 | 26447467 |
| chikungunya virus in macaques, malaysia. | | 0 | 26291585 |
| chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose. | chikungunya virus (chikv) is a mosquito-borne alphavirus that causes major epidemics of rash, fever, and debilitating arthritis. currently, there are no vaccines or antivirals available for prevention or treatment. we therefore generated 2 live-attenuated vaccine candidates based on the insertion of a picornavirus internal ribosome entry site (ires) sequence into the genome of chikv. vaccination of cynomolgus macaques with a single dose of either vaccine produced no signs of disease but was high ... | 2014 | 24403555 |
| chikungunya antibodies detected in non-human primates and rats in three indian ocean islands after the 2006 chikv outbreak. | the role of terrestrial vertebrates in the epidemiology of chikungunya disease is poorly understood. we evaluated their exposure and amplification role during the 2006 chikungunya outbreak in the indian ocean. blood samples were collected from 18 mammalian and reptile species from reunion island, mauritius and mayotte. among the 1051 samples serologically tested for chikungunya virus (chikv), two crab-eating macaques (macaca fascicularis) and two ship rats (rattus rattus) proved to be exposed to ... | 2014 | 24885529 |
| chikungunya virus infection in cynomolgus macaques following intradermal and aerosol exposure. | chikungunya virus (chikv) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. there are currently no licensed vaccines or antiviral therapeutics to protect against chikv infection in humans. animal models recapitulating human disease, especially for transmission by aerosol, are needed for licensure of such medical countermeasures. | 2017 | 28728590 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |