| antimicrobial activity of some indian medicinal plants. | the antimicrobial potential of seventy-seven extracts from twenty-four plants was screened against eight bacteria and four pathogenic fungi, using microbroth dilution assay. lowest concentration of the extract, which inhibits any visual microbial growth after treatment with p-iodonitrotetrazolium violet, was considered to be minimum inhibitory concentration (mic). water extracts of acacia nilotica, justicia zelanica, lantana camara and saraca asoca exhibited good activity against all the bacteri ... | 2007 | 20161895 |
| cytotoxic activity screening of bangladeshi medicinal plant extracts. | the cytotoxic activity of 23 crude methanol extracts from 19 bangladeshi medicinal plants was investigated against healthy mouse fibroblasts (nih3t3), healthy monkey kidney (vero) and four human cancer cell lines (gastric, ags; colon, ht-29; and breast, mcf-7 and mda-mb-231) using mtt assay. high cytotoxicity across all cell lines tested was exhibited by aegiceras corniculatum (fruit) and hymenodictyon excelsum (bark) extracts (ic50 values ranging from 0.0005 to 0.9980 and 0.08 to 0.44 mg/ml, re ... | 2014 | 23846168 |
| isolation, purification and characterization of a novel steroidal saponin cholestanol glucoside from lasiodiplodia theobromae that induces apoptosis in a549 cells. | search for novel anticancer lead molecules continues to be a major focus of cancer research due to the limitations of existing drugs such as lack of tumor selectivity, narrow therapeutic index and multidrug resistance of cancer types. natural molecules often possess better pharmacokinetic traits compared to synthetic molecules as they continually evolve by natural selection process to interact with biological macromolecules. microbial metabolites constitute nearly half of the pharmaceuticals in ... | 2016 | 26338072 |
| therapeutic effects of acetone extract of saraca asoca seeds on rats with adjuvant-induced arthritis via attenuating inflammatory responses. | saraca asoca has been traditionally used in indian system for treatment of uterine, genital, and other reproductive disorders in women, fever, pain, and inflammation. the hypothesis of this study is that acetone extract of saraca asoca seeds is an effective anti-inflammatory treatment for arthritis in animal experiments. the antiarthritic effect of its oral administration on freund's adjuvant-induced arthritis has been studied in wistar albino rats after acute and subacute toxicities. phytochemi ... | 2014 | 24729890 |
| pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of saraca asoca roxb. | to conduct a systemic evaluation of the medicinal value of seeds which include macroscopic and microscopic characterization, physiochemical evaluation, preliminary phytochemical screening and experimental antipyretic activity. | 2012 | 23569847 |
| Therapeutic effect of Saraca asoca (Roxb.) Wilde on lysosomal enzymes and collagen metabolism in adjuvant induced arthritis. | Rheumatoid arthritis is a chronic, progressive and systemic inflammatory disorder mainly affecting the synovial joints. In the present study, we evaluated the anti-arthritic effect of the methanol extract of Saraca asoca (Roxb.) Wilde., (Fabaceae) on adjuvant induced arthritis by assessing paw swelling, body weight, the levels of lysosomal enzymes, protein bound carbohydrates, serum cytokines, urinary collagen and histopathology of joints. It was found that S. asoca methanol extract at doses of ... | 2011 | 21947518 |
| chemoprevention of two-stage skin cancer in vivo by saraca asoca. | saraca asoca (family caesalpiniaceae) has been widely used in traditional indian medicine especially due to its wound-healing property. the present study investigates the chemopreventive property of flavonoids from saraca asoca (flowers) on 2-stage skin carcinogenesis in mice models. skin cancer was induced in swiss albino mice by single topical application of 7,12-dimethyl benzanthracene (100 µg/50 µl of acetone) followed by thrice a week treatment of croton oil for 20 weeks. the topical pretre ... | 2011 | 21771821 |
| the action of saraca asoca roxb. de wilde bark on the pgh2 synthetase enzyme complex of the sheep vesicular gland. | extracts of s. asoca bark and pure compounds isolated from the bark were tested for properties that might inhibit the conversion of arachidonic acid by the pgh2 synthetase. they were assayed spectrophotometrically with adrenaline as cofactor. methanol- and ethyl acetate extracts inhibited the conversion. the observed inhibition was confirmed in an oxygraphic assay. two procyanidin dimers from the ethyl acetate extract showed enzyme catalyzed oxidation in our assay. the ether extract of the bark ... | 1985 | 3931371 |