| tolerability and immunogenicity of an inactivated enterovirus 71 vaccine in chinese healthy adults and children: an open label, phase 1 clinical trial. | in this open labeled phase 1 clinical trial with enterovirus 71 (ev71) vaccine (clinicaltrials.gov number: nct01267903) performed in donghai county, jiangsu province, china, in january 2011. a total of 100 healthy participants, stratified by age (40 adults aged 16-22 y and 60 children aged 6-15 y), were enrolled from volunteers and sequentially received ev71 vaccines of 160u (only for children), 320u, or 640u on day 0 and 28, in a manner of dose escalation. all the participants were followed for ... | 2012 | 22634437 |
| [epidemiology and etiology of hand-foot-and-mouth disease seen in jiangsu province from 2008 to 2010]. | to analyze the etiological and epidemiological characteristics of hand-foot-and-mouth disease (hfmd) seen in jiangsu province from 2008 to 2010, and provide evidence for its prevention and control. | 2012 | 22801225 |
| enterovirus spectrum from the active surveillance of hand foot and mouth disease patients under the clinical trial of inactivated enterovirus a71 vaccine in jiangsu, china, 2012-2013. | epidemiological data from active surveillance on human enterovirus, which could cause hand, foot, and mouth disease, were limited. an active surveillance system was used to investigate the enterovirus spectrum and the incidence of different enteroviruses in infants aged 6-35 months in jiangsu province from 2012 to 2013. fifty-nine infants were randomly selected from 522 non-ev-a71/cv-a16 hfmd patients. we collected 173 throat swabs and 174 rectal swabs from these infants. rt-pcr was used to ampl ... | 2015 | 26010334 |
| seroepidemiology of coxsackievirus a6, coxsackievirus a16, and enterovirus 71 infections in infants and children: a prospective cohort study in jiangsu, china. | | 2016 | 27546063 |
| epidemiology of hand, foot, and mouth disease and genotype characterization of enterovirus 71 in jiangsu, china. | in the spring of 2008, an ev71-caused hand, foot, and mouth disease (hfmd) outbreak occurred in fuyang city, anhui province, china. jiangsu province that borders auhui to the east is presumed as a key station for the spread of ev71 to other regions of the yangtze river delta. | 2010 | 20719557 |
| [analysis on the epidemiological and genetic characteristics of enterovirus type 71 and coxsackie a16 virus infection in jiangsu, china]. | to determine the epidemiological features of hand-foot-and-mouth disease (hfmd) outbreaks and the genetic characteristics of enterovirus type 71(ev71) isolates from patients in lianyungang, jiangsu province in may, 2008. | 2009 | 19731523 |
| [analysis of seroepidemiology of enterovirus 71 diseases in children in jiangsu province]. | to analyze the dynamic pattern and the distributive characteristics of neutralizing antibody against enterovirus 71 (ev-a71 ) in children aged 6-35 months in jiangsu province from 2012 to 2014. | 2015 | 26887297 |
| seroepidemiology of human enterovirus71 and coxsackievirusa16 in jiangsu province, china. | the major etiology of hand, foot and mouth disease (hfmd) is infection with human enterovirus a (hev-a). among subtypes of hev-a, coxsackievirusa16 (coxa16) and enterovirus 71 (ev71) are major causes for recurrent hfmd among infants and children in jiangsu province, mainland china. here, we analyzed maternal antibodies between prenatal women and their neonates, to determine age-specific seroprevalence of human ev71 and coxa16 infections in infants and children aged 0 to 15 years. the results may ... | 2012 | 23102275 |
| two models for changes of ev71 immunity in infants and young children. | human enterovirus 71 (ev71) has been associated with outbreaks of hand-foot-and-mouth disease (hfmd) in china. susceptibility to ev71 is associated with age, but few studies have been accomplished to measure such a relationship. a better understanding of the connection between susceptibility and age is necessary to develop strategies for control of hfmd. in 2010, a survey of an epidemic of ev71 was conducted in a northern city of jiangsu province in china. samples were tested serologically to id ... | 2015 | 25906390 |
| phylogenetic analysis of the major causative agents of hand, foot and mouth disease in suzhou city, jiangsu province, china, in 2012-2013. | hand, foot and mouth disease (hfmd) is a serious public health problem that has emerged over the past several decades. pathogen detection by the chinese national hfmd surveillance system has focused mainly on enterovirus 71 (ev71) and coxsackievirus a16 (ca16). therefore, epidemiological information regarding the other causative enteroviruses is limited. to identify the pandemic enterovirus in suzhou, jiangsu province, china, clinical samples from patients with hfmd were collected from 2012 to 2 ... | 2015 | 26038764 |