| serologic evidence for the presence in pteropus bats of a paramyxovirus related to equine morbillivirus. | | 1996 | 8903239 |
| emerging infections in australia. | over the last 10 years, novel infectious agents including equine morbillivirus, lyssavirus, barmah forest virus, rickettsia honei and two as-yet-unnamed bunyaviruses have been identified as causes of human disease in australia. previously described agents, such as japanese b encephalitis virus, dengue virus, ross river virus, orientia tsutsugamushi, rickettsia australis, burkholderia pseudomallei, mycobacterium ulcerans and trichinella pseudospiralis, have increased their geographical distributi ... | 1997 | 9494666 |
| host and viral traits predict zoonotic spillover from mammals. | the majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern (for example, hiv, ebola and sars). understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmission, or spillover, are therefore key goals for pandemic surveillance programs. however, few analytical tools exist to identify which host species are likely to harbour the next human virus, or which viruses can cross species ... | 2017 | 28636590 |
| unexpected result of hendra virus outbreaks for veterinarians, queensland, australia. | a qualitative study of equine veterinarians and allied staff from queensland, australia, showed that veterinarians are ceasing equine practice because of fears related to hendra virus. their decisions were motivated by personal safety and legal liability concerns. | 2012 | 22261152 |
| hendra vaccine success announced. | | 2011 | 21834199 |
| hendra virus outbreak with novel clinical features, australia. | to determine the epidemiologic and clinical features of a 2008 outbreak of hendra virus infection in a veterinary clinic in australia, we investigated the equine case-series. four of 5 infected horses died, as did 1 of 2 infected staff members. clinical manifestation in horses was predominantly neurologic. preclinical transmission appears likely. | 2010 | 20113576 |
| functional studies of host-specific ephrin-b ligands as henipavirus receptors. | hendra virus (hev) and nipah virus (niv) are closely related paramyxoviruses that infect and cause disease in a wide range of mammalian hosts. to determine whether host receptor molecules play a role in species-specific and/or virus-specific infection we have cloned and characterized ephrin-b2 and ephrin-b3 ligands from a range of species, including human, horse, pig, cat, dog, bats (pteropus alecto and pteropus vampyrus) and mouse. hev and niv were both able to infect cells expressing any of th ... | 2008 | 18054977 |
| functional expression and membrane fusion tropism of the envelope glycoproteins of hendra virus. | hendra virus (hev) is an emerging paramyxovirus first isolated from cases of severe respiratory disease that fatally affected both horses and humans. understanding the mechanisms of host cell infection and cross-species transmission is an important step in addressing the risk posed by such emerging pathogens. we have initiated studies to characterize the biological properties of the hev envelope glycoproteins. recombinant vaccinia viruses encoding the hev f and g open reading frames were generat ... | 2001 | 11882997 |
| isolation of hendra virus from pteropid bats: a natural reservoir of hendra virus. | since it was first described in australia in 1994, hendra virus (hev) has caused two outbreaks of fatal disease in horses and humans, and an isolated fatal horse case. our preliminary studies revealed a high prevalence of neutralizing antibodies to hev in bats of the genus pteropus:, but it was unclear whether this was due to infection with hev or a related virus. we developed the hypothesis that hev excretion from bats might be related to the birthing process and we targeted the reproductive tr ... | 2000 | 10900029 |
| a fatal case of hendra virus infection in a horse in north queensland: clinical and epidemiological features. | | 2000 | 10840578 |
| expression of equine morbillivirus (emv) matrix and fusion proteins and their evaluation as diagnostic reagents. | full-length cdna clones coding for the matrix (m) and fusion (f) proteins of equine morbillivirus (emv) were isolated by rt-pcr, and expressed in escherichia coli using two different expression systems. western blot analysis indicated that the m and f proteins, expressed either by itself or as fusion proteins with glutathione s-transferase (gst), were insoluble and degraded after expression. analysis of the degradation pattern of recombinant m protein suggested that the n-terminus of the matrix ... | 1997 | 9672592 |
| emerging tropical diseases in australia. part 5. hendra virus. | hendra virus (hev) was first isolated in 1994, from a disease outbreak involving at least 21 horses and two humans in the brisbane suburb of hendra, australia. the affected horses and humans all developed a severe but unidentified respiratory disease that resulted in the deaths of one of the human cases and the deaths or putting down of 14 of the horses. the virus, isolated by culture from a horse and the kidney of the fatal human case, was initially characterised as a new member of the genus mo ... | 2011 | 21294944 |
| hendra virus: what do we know? | hendra virus infection is an emerging infectious disease that is not well understood. most cases of hendra virus infection have occurred in queensland, with one case in a horse in nsw. hendra virus infection has a high mortality rate in horses and humans and as cases could occur anywhere in australia it is important to be ready for prompt action should an outbreak occur in nsw. this paper: reviews the current knowledge on hendra virus infection including methods for preventing the disease; expla ... | 2011 | 21781619 |
| hendra virus infection in horses: a review on emerging mystery paramyxovirus. | hendra virus (hev) is a zoonotic paramyxovirus which causes acute and deadly infection in horses (equus caballus). it is a rare and unmanaged emerging viral infection in horses which is harbored by bats of the genus pteropus (australian flying foxes or fruit bats). the virus is pleomorphic in shape and its genome contains nonsegmented negative-stranded rna with 18234 nucleotides in length. the virus is transmitted from flying foxes to horses, horse to horse, and horse to humans. human-to-human t ... | 2020 | 32684248 |
| cryptic etiopathological conditions of equine nervous system with special emphasis on viral diseases. | the importance of horse (equus caballus) to equine practitioners and researchers cannot be ignored. an unevenly distributed population of equids harbors numerous diseases, which can affect horses of any age and breed. among these, the affections of nervous system are potent reason for death and euthanasia in equids. many episodes associated with the emergence of equine encephalitic conditions have also pose a threat to human population as well, which signifies their pathogenic zoonotic potential ... | 2017 | 29391683 |
| the lesions of experimental equine morbillivirus disease in cats and guinea pigs. | nine cats and four guinea pigs became affected with severe disease during experiments on the infectivity of equine morbillivirus, a newly recognized cause of respiratory disease in horses and humans. four of the cats were challenged by subcutaneous inoculation, two by intranasal installation, two by oral dosage, and one by direct contact with a cat previously infected by subcutaneous inoculation. all four guinea pigs were inoculated subcutaneously. gross pathology seen in all affected cats was c ... | 1997 | 9240841 |