Publications

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analysis of genetic mutations associated with anti-malarial drug resistance in plasmodium falciparum from the democratic republic of east timor.in response to chloroquine (cq) resistance, the policy for the first-line treatment of uncomplicated malaria in the democratic republic of east timor (dret) was changed in early 2000. the combination of sulphadoxine-pyrimethamine (sp) was then introduced for the treatment of uncomplicated falciparum malaria.200919358729
evidence-based malaria control in timor leste from 2006 to 2012.malaria has been a major public health problem in the newly established democratic republic of timor leste with over 200,000 cases being reported in 2006 and 2007. the national malaria control programme (nmcp) was established in 2003. the progress made in malaria control in timor leste is reported.201525890294
malaria and mefloquine prophylaxis use among japan ground self-defense force personnel deployed in east timor.malaria poses a significant threat to military personnel stationed in endemic areas; therefore, it is important to examine the risks of military operations, particularly in areas where malaria-related data are scarce. the recent deployment of japan ground self-defense force (jgsdf) for a peacekeeping operation in east timor provided an opportunity to investigate these risks. the results of these studies may be translated into chemoprophylactic strategies for travelers.200717617844
a case of fatal plasmodium falciparum malaria complicated by acute dengue fever in east timor.a case is reported of a seven-year-old girl who had concurrent infections with plasmodium falciparum malaria and dengue in a remote area of east timor. the diagnosis of malaria was delayed because of two false-negative results with malaria rapid diagnosis test cards. diagnosis was eventually made on microscopic examination of the patient's blood. despite treatment, the patient subsequently died. this case serves as a reminder of the fallibility of rapid diagnostic tests, and the importance of ex ...200616837729
efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated plasmodium falciparum malaria in east timor.the efficacy of sulfadoxine-pyrimethamine (sp) in east timor is unknown. we treated 38 individuals with uncomplicated plasmodium falciparum malaria with sp and monitored the outcome for 28 days. recrudescent parasitemia, confirmed by genotyping, were detected in three individuals resulting in a late treatment failure rate of 7.9% (95% confidence interval = 1.7-21.4%). the results suggest that sp is still efficacious in treating uncomplicated p. falciparum malaria in east timor. however, the usef ...200616525092
a retrospective analysis of the protective efficacy of tafenoquine and mefloquine as prophylactic anti-malarials in non-immune individuals during deployment to a malaria-endemic area.in 2000/2001, the australian defense forces (adf), in collaboration with smithkline beecham and the united states army, conducted a field trial to evaluate the safety, tolerability and efficacy of tafenoquine and mefloquine/primaquine for the prophylaxis of malaria amongst non-immune australian soldiers deployed to east timor (now called timor leste) for peacekeeping operations. the lack of a concurrent placebo control arm prevented an internal estimate of the malaria attack rate and so the prot ...201424502679
a retrospective study on imported malaria in jordan. 1. malaria among jordanian un peacekeeping forces.malaria is considered as one of the most threatening diseases affecting peacekeeping forces serving in malaria endemic countries. the jordanian armed forces participated in many of the united nations peacekeeping missions in over 20 countries across the world. thin and thick blood smears were collected from military personnel returning to jordan, and relevant data including occupation, age, sex, residence address and the country they served in were recorded. mefloquine 250 mg/week was prescribed ...201424639137
plasmodium vivax in the democratic republic of east timor: parasite prevalence and antifolate resistance-associated mutations.in the democratic republic of east timor, plasmodium falciparum and plasmodium vivax malaria coexist, but limited information is available about the latter species. consequently, the prevalence of p. vivax and of its corresponding antifolate resistance-associated mutations in the pvdhfr and pvdhps genes was assessed here. blood samples were collected from 650 individuals distributed among six districts, over two different periods, by either passive case detection (pcd) or active case detection ( ...201020412783
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