| mycobacterium africanum subtype ii is associated with two distinct genotypes and is a major cause of human tuberculosis in kampala, uganda. | the population structure of 234 mycobacterium tuberculosis complex strains obtained during 1995 and 1997 from tuberculosis patients living in kampala, uganda (east africa), was analyzed by routine laboratory procedures, spoligotyping, and is6110 restriction fragment length polymorphism (rflp) typing. according to biochemical test results, 157 isolates (67%) were classified as m. africanum subtype ii (resistant to thiophen-2-carboxylic acid hydrazide), 76 isolates (32%) were classified as m. tube ... | 2002 | 12202584 |
| genetic susceptibility to tuberculosis associated with cathepsin z haplotype in a ugandan household contact study. | tuberculosis (tb), caused by mycobacterium tuberculosis (mtb), causes 9 million new cases worldwide and 2 million deaths annually. genetic linkage and association analyses have suggested several chromosomal regions and candidate genes involved in tb susceptibility. this study examines the association of tb disease susceptibility with a selection of biologically relevant genes on regions on chromosomes 7 (il6 and card11) and 20 (ctsz and mc3r) and fine mapping of the chromosome 7p22-p21 region id ... | 2011 | 21354459 |
| genome scan of m. tuberculosis infection and disease in ugandans. | tuberculosis (tb), caused by mycobacterium tuberculosis (mtb), is an enduring public health problem globally, particularly in sub-saharan africa. several studies have suggested a role for host genetic susceptibility in increased risk for tb but results across studies have been equivocal. as part of a household contact study of mtb infection and disease in kampala, uganda, we have taken a unique approach to the study of genetic susceptibility to tb, by studying three phenotypes. first, we analyze ... | 2008 | 19116662 |