| deletion of the coffin-lowry syndrome gene rsk2 in mice is associated with impaired spatial learning and reduced control of exploratory behavior. | coffin-lowry syndrome (cls) is an x-linked syndromic form of mental retardation associated with skeletal abnormalities. it is caused by mutations of the rsk2 gene, which encodes a growth factor regulated kinase. gene deletion studies in mice have shown an essential role for the rsk2 gene in osteoblast differentiation and function, establishing a causal link between rsk2 deficiency and skeletal abnormalities of cls. although analyses in mice have revealed prominent expression of rsk2 in brain str ... | 2007 | 17033934 |