| metabolic effects of the gly1057asp polymorphism in irs-2 and interactions with obesity. | insulin receptor substrate (irs)-2 plays an important role in insulin signaling and its disruption results in diabetes in mice. in humans, the irs-2 gly1057asp substitution was associated with lower risk of type 2 diabetes in lean individuals, but with a higher risk in obese individuals. to clarify the role of irs-2 on the development of type 2 diabetes and obesity in pima indians, and particularly to investigate whether the effects of the gly1057asp polymorphism on metabolism are mediated by ob ... | 2003 | 12765968 |