| role for the paramyxovirus genomic promoter in limiting host cell antiviral responses and cell killing. | the parainfluenza virus simian virus 5 (sv5) is a poor inducer of innate immune responses. in contrast, the naturally occurring sv5 variant wake forest parainfluenza virus (wf-piv) activates the synthesis of proinflammatory cytokines and beta interferon (ifn-beta). comparison of sv5 and wf-piv genome sequences revealed nine nucleotide differences within the viral genomic promoter, including two substitutions (u5c and a14g) in the most highly conserved 3'-end promoter element. to test the consequ ... | 2009 | 19587032 |