| bacterial genetic signatures of human social phenomena among m. tuberculosis from an aboriginal canadian population. | despite a widespread global distribution and highly variable disease phenotype, there is little dna sequence diversity among isolates of mycobacterium tuberculosis. in addition, many regional population genetic surveys have revealed a stereotypical structure in which a single clone, lineage, or clade makes up the majority of the population. it is often assumed that dominant clones are highly adapted, that is, the overall structure of m. tuberculosis populations is the result of positive selectio ... | 2010 | 19861642 |
| dispersal of mycobacterium tuberculosis via the canadian fur trade. | patterns of gene flow can have marked effects on the evolution of populations. to better understand the migration dynamics of mycobacterium tuberculosis, we studied genetic data from european m. tuberculosis lineages currently circulating in aboriginal and french canadian communities. a single m. tuberculosis lineage, characterized by the ds6(quebec) genomic deletion, is at highest frequency among aboriginal populations in ontario, saskatchewan, and alberta; this bacterial lineage is also domina ... | 2011 | 21464295 |