| a nonpromoting phorbol from the samoan medicinal plant homalanthus nutans inhibits cell killing by hiv-1. | extracts of homalanthus nutans, a plant used in samoan herbal medicine, exhibited potent activity in an in vitro, tetrazolium-based assay which detects the inhibition of the cytopathic effects of human immunodeficiency virus (hiv-1). the active constituent was identified as prostratin, a relatively polar 12-deoxyphorbol ester. noncytotoxic concentrations of prostratin from greater than or equal to 0.1 to greater than 25 microm protected t-lymphoblastoid cem-ss and c-8166 cells from the killing e ... | 1992 | 1597853 |