[m129v prnp gene polymorphism in castilla y león shows a similar distribution to other spanish regions and other european countries].it has been reported that the polymorphism m129v in the prnp gene modifies the phenotype in all the subtypes of prion diseases in humans. all cases diagnosed to date as suffering the human variant of mad cow disease (vcjd) carry the allele 129m. in the last five years five cases of vcjd have been reported in spain, three of them in castilla y león (in western spain). observation of differences in the genotypic frequency of this polymorphism in different populations prompted us to analyze the dis ...201020004419
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