| developmental and tissue-specific expression of ahr1, ahr2, and arnt2 in dioxin-sensitive and -resistant populations of the marine fish fundulus heteroclitus. | fundulus heteroclitus is a well-characterized marine fish model for studying aryl hydrocarbon toxicity. the f. heteroclitus population in new bedford harbor (nbh), a superfund site in southeastern massachusetts, exhibits heritable resistance to the toxic effects of planar halogenated aromatic hydrocarbons (phahs), including 2,3,7, 8-tetrachlorodibenzo-p-dioxin (tcdd) and polychlorinated biphenyls (pcbs). to investigate the role of the aryl hydrocarbon receptor (ahr) signal transduction pathway i ... | 2000 | 11006353 |
| population genetic structure of a nonmigratory estuarine fish (fundulus heteroclitus) across a strong gradient of polychlorinated biphenyl contamination. | populations of the estuarine fish fundulus heteroclitus indigenous to contaminated sites exhibit heritable resistance to some of the toxic effects of early life-stage exposure to polychlorinated biphenyls (pcbs). this evolved tolerance provides evidence of strong selection by pcbs, and it suggests other potential genetic effects of these stressors on resident populations. environmental contaminants have the potential to affect the genetic structure of populations and to reduce genetic diversity, ... | 2005 | 15779774 |
| regulation of pregnane-x-receptor, cyp3a and p-glycoprotein genes in the pcb-resistant killifish (fundulus heteroclitus) population from new bedford harbor. | killifish survive and reproduce in the new bedford harbor (nbh) in massachusetts (ma), usa, a site severely contaminated with polychlorinated biphenyls (pcbs) for decades. levels of 22 different pcb congeners were analyzed in liver from killifish collected in 2008. concentrations of dioxin-like pcbs in liver of nbh killifish were ∼400 times higher, and the levels of non-dioxin-like pcbs ∼3000 times higher than in killifish from a reference site, scorton creek (sc), ma. the nbh killifish are know ... | 2015 | 25553538 |
| aryl hydrocarbon receptor polymorphisms and dioxin resistance in atlantic killifish (fundulus heteroclitus). | the aryl hydrocarbon receptor (ahr) gene encodes a ligand-activated transcription factor through which planar halogenated aromatic hydrocarbons (hahs) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) as well as polynuclear aromatic hydrocarbons (pahs) cause altered gene expression and toxicity. to understand the role of ahr genetic variability in differential sensitivity to hahs and pahs, we are currently studying a population of the teleost fundulus heteroclitus (atlantic killifish) that has ... | 2004 | 15077014 |
| evolution of tolerance to pcbs and susceptibility to a bacterial pathogen (vibrio harveyi) in atlantic killifish (fundulus heteroclitus) from new bedford (ma, usa) harbor. | a population of the non-migratory estuarine fish fundulus heteroclitus (atlantic killifish) resident to new bedford (nb), massachusetts, usa, an urban harbor highly contaminated with polychlorinated biphenyls (pcbs), demonstrates recently evolved tolerance to some aspects of pcb toxicity. pcb toxicology, ecological theory, and some precedence supported expectations of increased susceptibility to pathogens in nb killifish. however, laboratory bacterial challenges of the marine pathogen vibrio har ... | 2009 | 19110353 |