| effect of desmodium adscendens fraction 3 on contractions of respiratory smooth muscle. | the third flash chromatography fraction prepared from an aqueous extract of desmodium adscendens leaves (daf3) was evaluated for pharmacological activity using contractions of tracheal spirals and lung parenchymal strips caused by ovalbumin, arachidonic acid, histamine and carbachol. daf3 inhibited both the early and late phases of antigen-induced contractions of both tissues dose-dependently, but had no effect on arachidonic-induced contractions. with tracheal spirals, the inhibition occurred w ... | 1990 | 2120518 |
| dose-response effects of desmodium adscendens aqueous extract on histamine response, content and anaphylactic reactions in the guinea pig. | different concentrations of a hot water extract of desmodium adscendens, a plant used in ghana to control asthmatic attacks, were used in drinking water to evaluate the plant's anti-anaphylactic properties in guinea pigs. the results show that the extract's inhibition of histamine-induced ileal contraction is largely competitive and that its effect of reducing lung histamine content is dose-dependent. the results also show that the extract causes a dose-dependent reduction in the amount of spasm ... | 1986 | 2434805 |
| effect of desmodium adscendens fractions on antigen- and arachidonic acid-induced contractions of guinea pig airways. | three fractions (n-butanol, f2, and l5), isolated from an aqueous extract of desmodium adscendens, a plant used in ghana for the management of asthma, were evaluated for their pharmacological activity using ovalbumin and arachidonic acid-induced contractions of guinea pig airways. all three fractions inhibited the ovalbumin-induced contractions of indomethacin-pretreated tracheal spirals from sensitized animals dose dependently, but only l5 and n-butanol inhibited such contractions in the absenc ... | 1988 | 3139272 |
| effects of the extracts of desmodium adscendens on anaphylaxis. | desmodium adscendens, used by herbalists in ghana for the treatment of asthma, is anti-anaphylactic in vitro. as the plant material is administered orally, in vivo studies of its anti-anaphylactic property were undertaken using the guinea-pig. the results show that both aqueous and ethanolic extracts of d. adscendens, when taken orally, reduce anaphylactic contractions, interfere with histamine-induced contractions, and reduce the amount of smooth muscle stimulating substances released from lung ... | 1984 | 6482479 |
| an activator of calcium-dependent potassium channels isolated from a medicinal herb. | large-conductance calcium-dependent potassium (maxi-k) channels play an important role in regulating the tone of airway smooth muscle and the release of bronchoconstrictive substances from nerves in the lung. crude extracts of desmodium adscendens, a medicinal herb used in ghana as a treatment for asthma, inhibit binding of monoiodotyrosine charybdotoxin (125i-chtx) to receptor sites in bovine tracheal smooth muscle membranes that have been shown to be associated with maxi-k channels. using this ... | 1993 | 7685635 |
| effects of an ethanolic extract of desmodium adscendens on central nervous system in rodents. | this study investigates some pharmacological effects of the ethanolic extract of the leaves of desmodium adscendens (papillionaceae), a medicinal plant in the african traditional medicine, on the central nervous system. the plant extract induced hypothermia and had analgesic effect in mice. d. adscendens suppressed the tonic phase of convulsion and mortality induced by pentylenetetrazole (ptz) in mice. in addition, the plant extract delayed the onset of ptz forelimb clonus, and generalized limbi ... | 1996 | 8735451 |
| free-radical scavenging action of medicinal herbs from ghana: thonningia sanguinea on experimentally-induced liver injuries. | the antioxidant action of medicinal herbs used in ghana for treating various ailments was evaluated in vitro and in vivo. five plants, desmodium adscendens, indigofera arrecta, trema occidentalis, caparis erythrocarpus, and thonningia sanguinea were tested for their free radical scavenging action by their interaction with 1,1-diphenyl-2-picrylhydrazyl (dpph). of these five plants, only thonningia sanguinea was found to scavenge the dpph radical. lipid peroxidation in liver microsomes induced by ... | 1999 | 10401991 |
| extract of ocimum canum lowers blood glucose and facilitates insulin release by isolated pancreatic beta-islet cells. | aqueous extract of ocimum canum sim, (lamiaceae) is used by some ghanaians to manage diabetes mellitus. in vivo modulation of levels of fasting blood glucose by 0. canum extract was evaluated in type-ii diabetes mellitus using the c57bl/ksj db/db genetically diabetic animal model, and its effects on glucose-stimulated insulin release in vitro were monitored using isolated rat pancreatic beta-islet cells. the results showed that fasting blood glucose levels and body weight decreased significantly ... | 2002 | 12120816 |
| effect of butanolic fraction of desmodium adscendens on the anococcygeus of the rat. | the chemical composition of plants can vary according to factors such as soil and time of collection. desmodium adscendens (sw.) d.c. var. adscendens (papillionaceae) is a plant employed in the treatment of asthma in ghana, africa. studies have shown that butanolic extract inhibits contraction of the ileum and trachea in guinea pigs. in mato grosso, this plant is used only in the treatment of ovarian inflammation. the objective of this work was to verify if the plant found in mato grosso also re ... | 2002 | 12489394 |
| an ethnomedicinal, phytochemical and pharmacological profile of desmodium gangeticum (l.) dc. and desmodium adscendens (sw.) dc. | desmodium gangeticum (l.) dc. and desmodium adscendens (sw.) dc. are two important and well explored species of genus desmodium (fabaceae (alt. leguminosae) subfamily: faboideae). desmodium gangeticum is used as a tonic, febrifuge, digestive, anticatarrhal, antiemitic, in inflammatory conditions of chest and in various other inflammatory conditions in the ayurvedic system of medicine while desmodium adscendens is widely used for the treatment of asthma in ghana, africa. | 2011 | 21530632 |
| tracheal relaxation of five ivorian anti-asthmatic plants: role of epithelium and k⁺ channels in the effect of the aqueous-alcoholic extract of dichrostachys cinerea root bark. | leaves of boerhavia diffusa (nyctaginaceae), baphia nitida, cassia occidentalis, desmodium adscendens (fabaceae), and root bark of dichrostachys cinerea (fabaceae) are used in ivory coast for the treatment of asthma. the aim of this study was to evaluate the potential airway relaxant activity of different extracts of these plants. | 2011 | 21963567 |
| safety of desmodium adscendens extract on hepatocytes and renal cells. protective effect against oxidative stress. | the increased consumption of traditional medicinal plants has been driven by the notion that herbal products are safe and efficient. the purpose of this study was to evaluate the safety and the protective effect of a hydro alcoholic extract of desmodium adscendens (da) on liver (hepg2) and kidney (llc-pk1) cells. | 2017 | 26401376 |
| activity-guided isolation, identification and quantification of biologically active isomeric compounds from folk medicinal plant desmodium adscendens using high performance liquid chromatography with diode array detector, mass spectrometry and multidimentional nuclear magnetic resonance spectroscopy. | the antioxidant activity of the crude extract (60% ethanol) from the leaves of desmodium adscendens (sw.) dc. (fabaceae) was observed in dpph, xanthine/xanthine oxidase, lipid peroxydation and neutrophils burst tests. further activity-guided fractionation on c18 column (water, 20% methanol, 50% methanol and 100% methanol) resulted in the separation of the fraction (50% methanol) with the highest antioxidant capacity. hplc-dad analysis of biologically active fraction revealed the presence of two ... | 2015 | 25240729 |
| qualitative characterization of desmodium adscendens constituents by high-performance liquid chromatography-diode array ultraviolet-electrospray ionization multistage mass spectrometry. | the many effects of the african medicinal herb desmodium adscendens were studied in the 1980s and 1990s. in spite of this, a comprehensive analytical protocol for the quality control of its constituents (soyasaponins, alkaloids and flavonoids) has not yet been formulated and reported. this study deals with the optimization of extraction conditions from the plant and qualitative identification of the constituents by hplc-diode array uv and multistage mass spectrometry. plant constituents were ext ... | 2013 | 23841221 |
| antihepatotoxic activity of a quantified desmodium adscendens decoction and d-pinitol against chemically-induced liver damage in rats. | the isolation of d-pinitol (or 3-o-methyl-d-chiro-inositol) from an aqueous decoction of desmodium adscendens (fabaceae) leaves and twigs is reported. the protective and curative effect of this decoction, in which d-pinitol was quantified, and of pure d-pinitol, against chemically-induced liver damage in rats has been evaluated. | 2013 | 23291573 |
| chemical composition and, cellular evaluation of the antioxidant activity of desmodium adscendens leaves. | desmodium adscendens plant is widely used as juice or tea in various parts of the world against a wide range of diseases. this study determines the quality and the quantity of polyphenols, flavonoids, anthocyanins, and tannins in d. adscendens leaves by uv-spectrophotometry and rp-hplc methods. in addition, the antioxidant capacity of these phenolic compounds is evaluated by abts (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic)), dpph (2,2-diphenyl-1 picrylhydrazyl), and cellular tests. d. ads ... | 2011 | 20976084 |
| some secondary plant metabolites in desmodium adscendens and their effects on arachidonic acid metabolism. | the effects of three chemically different groups of compounds, (triterpenoid saponins, beta-phenylethylamines and tetrahydroisoquinolines), known to be present in desmodium adscendens, on plasma membrane ion channel, cytochrome p450 nadph-dependent oxygenation of arachidonic acid, and production of prostaglandins by the cyclooxygenase enzyme system, are described. the very high-conductance calcium-activated potassium ion channel, which is responsible for the maintenance of tone in smooth muscles ... | 1992 | 1438471 |