| comparison of enzyme-linked immunosorbent and indirect immunofluorescence assays for the detection of human t-cell lymphotropic virus type-i antibodies in sera from rural haiti. | serum samples were obtained from 340 healthy individuals without evidence of neurologic disease living in rural haiti. sera were screened for antibodies to human t-cell lymphotropic virus type i (htlv-i) using two commercially available enzyme immunoassays (eia) and by an indirect immunofluorescence assay (ifa) using a mixture of uninfected h9 cells and htlv-i-infected mt-2 cells. repeatedly positive samples were confirmed by western blot (wb). results with the two eia systems were concordant an ... | 1992 | 1572136 |
| induction of cd4+, human t lymphotropic virus type-1-specific cytotoxic t lymphocytes from patients with ham/tsp. recognition of an immunogenic region of the gp46 envelope glycoprotein of human t lymphotropic virus type-1. | although the humoral response to human t lymphotropic virus type-1 (htlv-i) has been well characterized in patients with htlv-i-associated neurologic disease (ham/tsp), little is known about a functional htlv-i-specific human t cell response, such as ctl, in these patients. to define both the phenotype of the responding ctl and the fine specificity of this response, long term t cell lines were generated from two ham/tsp patients who were from two different countries. patient's peripheral blood l ... | 1991 | 1704032 |
| molecular cloning of human t-cell lymphotrophic virus type i-like proviral genome from the peripheral lymphocyte dna of a patient with chronic neurologic disorders. | human t-cell lymphotropic virus type 1 (htlv-i), the etiologic agent of human t-cell leukemia, has recently been shown to be associated with neurologic disorders such as tropical spastic paraparesis, htlv-associated myelopathy, and possibly with multiple sclerosis. in this communication, we have examined one specific case of neurologic disorder that can be classified as multiple sclerosis or tropical spastic paraparesis. the patient suffering from chronic neurologic disorder was found to contain ... | 1988 | 2897123 |