Publications

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the peopling of the pacific from a bacterial perspective.two prehistoric migrations peopled the pacific. one reached new guinea and australia, and a second, more recent, migration extended through melanesia and from there to the polynesian islands. these migrations were accompanied by two distinct populations of the specific human pathogen helicobacter pylori, called hpsahul and hspmaori, respectively. hpsahul split from asian populations of h. pylori 31,000 to 37,000 years ago, in concordance with archaeological history. the hpsahul populations in ne ...200919164753
t(11;18)(q21;q21) in gastric malt lymphoma and diffuse large b-cell lymphoma of chinese patients.t(11;18)(q21;q21) occurs at variable frequencies in mucosa-associated lymphoid tissue (malt) lymphomas of different sites. in gastric malt lymphoma, it occurs in 30% cases and the translocation positive tumours are frequently at advanced stages and do not respond to helicobacter pylori eradication. intriguingly, t(11;18)(q21;q21) has been observed only rarely in mucosal diffuse large b-cell lymphomas (dlbcl), despite that at least a proportion of these tumours are believed to be the result of tr ...200314502259
time-dependent amplified pharmacokinetic and pharmacodynamic responses of rabeprazole in cytochrome p450 2c19 poor metabolizers.to determine the pharmacokinetic and pharmacodynamic rationale for the optimum regimen of rabeprazole in the treatment of helicobacter pylori infection in patients who are cytochrome p450 (cyp) 2c19 poor metabolizers or extensive metabolizers.200312820812
serum levels of pepsinogen i in healthy volunteers and patients with gastric ulcers and gastric carcinoma in taiwan.in order to investigate the clinical usefulness of human pepsinogen i (pgi) as a noninvasive diagnostic tool for gastric lesions, 92 healthy volunteers, 87 patients with a gastric ulcer and 94 patients with gastric carcinoma, verified by histologic examinations, were enrolled. the serum level of pgi in each patient was measured by radioimmunoassay. mean serum pgi levels were 95.4 +/- 39.4 ng/ml in patients with gastric ulcers, 77.6 +/- 29.3 ng/ml in healthy volunteers, and 52.1 +/- 26.5 ng/ml in ...19937904845
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