Publications

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hiv infection in healthy persons in uganda.the results of several serological surveys, carried out in uganda in the last 2 years, show that hiv infection is present in a number of different groups of individuals. there is a wide range of seropositivity (0 to 67.7%) seen within uganda. in the sexually inactive, whether primary school pupils or residents of old people's homes, no serological evidence of hiv infection was found. in young adults in kampala the hiv seropositivity ranged from 10.6 to 24.1%, whereas in rural adults the range wa ...19873126769
increasing prevalence of tuberculosis among mulago hospital admissions, kampala, uganda (1985-1989).tuberculosis, a major public health problem, was thought to be on the increase in mulago hospital, kampala, uganda, in the years 1985-1989. in order to verify and quantify the problem of tuberculosis in this hospital, we obtained total yearly hospital admissions and total yearly tuberculosis registrations for the years 1985-1989, and individually reviewed all available case records over the same period. from 1985-1989 the number of tuberculosis patients in this hospital practically doubled (835 ...19938324203
verbal autopsy as a tool for diagnosing hiv-related adult deaths in rural uganda.in general, information on the causes of adult deaths in developing countries is scarce. more specifically, relatively little is known about the effect of hiv-1 associated disease on adult mortality in general populations. in this study we have used a verbal autopsy technique to ascertain whether adult deaths were associated with hiv-1 in a rural population with a prevalence of hiv-1 infection of 8%, and used hiv-1 antibody status to validate the verbal autopsy findings.19968671573
the effect of human immunodeficiency virus-1 infection and stunting on measles immunoglobulin-g levels in children vaccinated against measles in uganda.measles is an important public health problem in developing nations and there is concern that immune response to measles vaccination may be compromised by paediatric human immunodeficiency virus (hiv) infection. therefore, this study investigated the relationship of immunoglobulin-g (ig-g) antibody levels in children vaccinated against measles and hiv-1 infection. further analysis was done to assess the influence of nutritional status on this relationship.199910342701
comparison of intestinal function in human immunodeficiency virus-seropositive patients in kampala and london.white homosexual men with human immunodeficiency virus (hiv) show progressive impairment of intestinal function assessed in terms of intestinal permeability and absorptive capacity. in this study we aimed to determine the effects of heterosexually acquired hiv on small-intestinal function in native africans, among whom there is a high prevalence of tropical enteropathy.199910423065
evaluating herbal medicine for the management of herpes zoster in human immunodeficiency virus-infected patients in kampala, uganda.this study was carried out to evaluate the potential effectiveness of herbal treatments used for herpes zoster (hz) by a great number of people living with acquired immunodeficiency syndrome (plwas) in uganda.199910630349
efficacy of an unsupervised 8-month rifampicin-containing regimen for the treatment of pulmonary tuberculosis in hiv-infected adults. uganda-case western reserve university research collaboration.national tuberculosis treatment centre, mulago hospital, kampala, uganda.200011092715
community-based trials of sexually transmitted disease treatment: repercussions for epidemiology and hiv prevention.this paper reviews the scientific basis for trials exploring the relation between sexually transmitted diseases (stds) and human immunodeficiency virus (hiv) infection in mwanza in the united republic of tanzania and rakai and masaka in the republic of uganda. the importance of a study's location and explanations for the divergent results of these trials are discussed. the modest effect on stds seen in the trial of syndromic management in mwanza, in contrast to the 38% reduction in the incidence ...200311217667
prevalence of kaposi sarcoma-associated herpesvirus compared with selected sexually transmitted diseases in adolescents and young adults in rural rakai district, uganda.kaposi sarcoma-associated herpesvirus (kshv) is transmitted by routes such as homosexual intercourse and is associated with hiv infection in industrialized countries. however, there is little information about its transmission in developing countries where kaposi sarcoma is an endemic disease.200111234789
the quality of care by private practitioners for sexually transmitted diseases in uganda.one of the limited number of strategies available to reduce the spread of human immunodeficiency virus (hiv) infections in sub-saharan africa is the effective treatment of other, curable, sexually transmitted diseases (stds). at present, a large proportion of people with stds either treat themselves at home or seek treatment from private sector practitioners (psps) rather than use publicly funded services. a randomized controlled trial of the efficacy of a behavioural intervention with or withou ...200111238428
severity of human immunodeficiency virus infection is associated with decreased phase angle, fat mass and body cell mass in adults with pulmonary tuberculosis infection in uganda.although coinfection with tuberculosis and human immunodeficiency virus (hiv) is emerging as a major problem in many developing countries, nutritional status has not been well characterized in adults with tuberculosis and hiv infection. we compared nutritional status between 261 hiv-positive and 278 hiv-negative adults with pulmonary tuberculosis in kampala, uganda, using anthropometry and bioelectrical impedance analysis. among 163 hiv-positive and 199 hiv-negative men, intracellular water-to-e ...200111694606
iga antibodies to human immunodeficiency virus in serum, saliva and urine for early diagnosis of immunodeficiency virus infection in ugandan infants.the value of hiv-1 iga antibodies for early diagnosis of hiv infection in infants in serum, saliva and urine was investigated at mulago hospital, kampala. sensitivity and specificity in serum of hiv-infected infants at different ages were: 0 to 1 months, 88 and 95%; 1 to 3 months, 88 and 97%; 4 to 6 months, 80 and 96%. they decreased between 67 and 77% and 80 to 91%, respectively, in older age groups. sensitivity for saliva was lower (53 to 79%) and urine only 37 to 62%, although specificity was ...200312613456
effect of periodic vitamin a supplementation on mortality and morbidity of human immunodeficiency virus-infected children in uganda: a controlled clinical trial.we investigated whether vitamin a supplementation would decrease mortality and morbidity rates in children infected with the human immunodeficiency virus (hiv).200515661475
assessing the health status of young aids and other orphans in kampala, uganda.the huge number of human immunodeficiency virus (hiv)/acquired immunodeficiency syndrome (aids) orphans is an important feature of the epidemic in sub-saharan africa. there are few and conflicting data on the effects of being orphaned on health and nutrition in the highly affected hiv endemic areas of africa. this study reports findings from a cross-sectional survey on associations between orphan status and health and nutrition parameters in young children of urban uganda. a high prevalence of o ...200515730503
cost-effectiveness of including tuberculin skin testing in an ipt program for hiv-infected persons in uganda.tuberculosis (tb) is the most common opportunistic infection among persons with human immunodeficiency virus or the acquired immune-deficiency syndrome (hiv/aids). isoniazid preventive therapy (ipt) effectively treats latent tb infection (ltbi) and prevents progression to active tb.200616776453
outcomes of cryptococcal meningitis in uganda before and after the availability of highly active antiretroviral therapy.cryptococcal meningitis (cm) is the proximate cause of death in 20%-30% of persons with acquired immunodeficiency syndrome in africa.200818433339
determinants of incidence and clearance of high-risk human papillomavirus infections in rural rakai, uganda.we used self-administered vaginal swabs to assess the incidence and clearance of carcinogenic human papillomavirus (hpv) infections in rural rakai, uganda.200818559545
hiv-1 transmission, by stage of infection.the epidemiological impact of public health interventions targeted at reducing transmission of human immunodeficiency virus type 1 (hiv-1) during early or late-stage infection depends on the contribution of these disease stages to transmission within a particular epidemic.200818662132
the effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in rakai, uganda.the objective of the study was to assess effects of male circumcision on female genital symptoms and vaginal infections.200918976733
geographic hiv type 1 subtype distribution in rakai district, uganda.to analyze hiv-1 subtype distribution, sequence analysis was performed on serum specimens obtained in 1994 from the rakai health sciences community cohort in uganda. portions of gag-p24 and env-gp41 were sequenced and hiv subtype was determined for 773 subjects residing in 10 community clusters in rural uganda. subtypes a (17%) and d (70%) were the most common strains in the population. subtype distribution varied by geographic region with significantly more subtype a in northern community clust ...200919803713
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