| high level of multidrug resistance mutations in hiv type 1 pol gene and resistance-associated mutations to enfuvirtide (t-20) among antiretroviral-experienced patients from central brazil. | hiv-1 resistance mutations to antiretroviral (arv) drugs (nucleoside reverse transcriptase inhibitors, nrti; nonnucleoside reverse transcriptase inhibitors, nnrti; and protease inhibitors, pi) represent a challenge for sustainable virologic and immunologic responses. hiv-1 phylogenetic diversity and arv resistance mutations associated with protease (pr) and reverse transcriptase (rt) were assessed among 48 arv-experienced patients from goiania/goias, central west brazil. the gp41 resistance muta ... | 2009 | 19792869 |
| hiv-1 primary and secondary antiretroviral drug resistance and genetic diversity among pregnant women from central brazil. | antiretroviral (arv) resistance mutations in hiv-1 may reduce the efficacy of prophylactic therapy to mother-to-child transmission and impact future treatment options. arv resistance mutations and hiv-1 phylogenetic diversity in protease (pr) and reverse transcriptase (rt) genes were assessed among 77 pregnant women (35 naïve, 42 treated with arv) from goiânia/goiás, central west brazil. arv mutations in pr/rt genes were analyzed against the stanford database, pr/rt hiv-1 subtypes were assigned ... | 2010 | 20087934 |