Publications

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hospital-based study of sexually transmitted diseases at murewa rural district hospital, zimbabwe 1991-1992.in zimbabwe, sexually transmitted diseases are highly prevalent and represent a significant amount of the workload for physicians.19957709319
human immunodeficiency virus (hiv) types western blot (wb) band profiles as potential surrogate markers of hiv disease progression and predictors of vertical transmission in a cohort of infected but antiretroviral therapy naïve pregnant women in harare, zimbabwe.expensive cd4 count and viral load tests have failed the intended objective of enabling access to hiv therapy in poor resource settings. it is imperative to develop simple, affordable and non-subjective disease monitoring tools to complement clinical staging efforts of inexperienced health personnel currently manning most healthcare centres because of brain drain. besides accurately predicting hiv infection, sequential appearance of specific bands of wb test offers a window of opportunity to dev ...201121211021
genital ulcers and transmission of hiv among couples in zimbabwe.seventy-five married men found to be positive for hiv-1 in harare, zimbabwe, were interviewed in order to define behaviours associated with acquisition of infection and to determine factors associated with transmission of infection to their wives. the majority of infected men reported sexual intercourse with multiple heterosexual partners and female prostitutes, and gave a history of sexually transmitted diseases (stds). all subjects denied homosexual activity and parenteral drug abuse. serologi ...19892508713
breastfeeding: breast milk banks and human immunodeficiency virus.hiv in infants and children in zimbabwe is virtually limited to vertical transmission. less than 5 cases of transfusion acquired hiv infections have been documented to date. zimbabwe was the third country in the world after the united states, to screen transfusion blood and blood products. the controversy of hiv transmission through breast milk is still far from resolved. in developing countries, breast-milk substitutes for formulae are not only prohibitively expensive but dangerous because of u ...19902092885
lung abscess in children in harare, zimbabwe.despite the rarity of lung abscess in children, 24 patients were treated at harare central hospital during the 10 year period (1979 to 1988). the bacteriology and clinical findings of the 24 patients are presented. bacteria were isolated from 18 patients. the most frequent isolates were staphylococcus aureus, group a beta haemolytic streptococci, and pseudomonas aeroginosa. most of the abscesses followed measles, empyema or an episode of aspiration. the patients were managed with bronchoscopy, p ...19921473506
interpreting tuberculin skin tests in a population with a high prevalence of hiv, tuberculosis, and nonspecific tuberculin sensitivity.understanding the epidemiology and clinical course of tuberculosis is hampered by the absence of a perfect test for latent tuberculosis infection. the tuberculin skin test (tst) is widely used but suffers poor specificity in those receiving the bacille calmette-guérin vaccine and poor sensitivity in individuals with human immunodeficiency virus (hiv) infections. tst responses for a target population in harare, zimbabwe (hiv prevalence, 21%), recruited in 2005-2006, were interpreted by using a se ...201020382638
ocular surface squamous neoplasia (ossn) and human immunodeficiency virus at sekuru kaguvi eye unit in zimbabwe: the role of operational research studies in a resource poor environment?to determine the extent of association and relative risk of developing ocular surface squamous neoplasia (ossn) among hiv positive patients seen in july 2004 at sekuru kaguvi eye unit, in harare, zimbabwe.200618254456
chronic cough in primary health care attendees, harare, zimbabwe: diagnosis and impact of hiv infection.cough lasting for > or = 3 weeks (i.e., chronic cough) indicates that a patient has suspected tuberculosis (tb). at the primary health care level, the spectrum of disease that causes chronic cough has not been previously investigated in a setting with a high prevalence of human immunodeficiency virus (hiv) infection.200515909272
high rates of clustering of strains causing tuberculosis in harare, zimbabwe: a molecular epidemiological study.we examined the pattern of tuberculosis (tb) transmission (i.e., reactivation versus recent transmission) and the impact of human immunodeficiency virus (hiv) infection in harare, zimbabwe. consecutive adult smear-positive pulmonary tb patients presenting to an urban hospital in harare were enrolled. a detailed epidemiological questionnaire was completed, and tests for hiv type 1 and cd4 cell counts were performed for each patient. molecular fingerprinting of the genomic dna recovered from cultu ...200415472306
relationship of kaposi sarcoma (ks)-associated herpesvirus viremia and ks disease in zimbabwe.the relationship between kaposi sarcoma-associated herpesvirus (kshv) viremia and ks disease was investigated in 500 subjects who received treatment in harare, zimbabwe. subjects were grouped by results of human immunodeficiency virus (hiv) type 1 serological tests, ks diagnosis, and ks clinical stage. the plasma kshv dna concentration was associated with concomitant ks and hiv-1 infection (aids-ks; p<.001) and aids-ks clinical stage (p=.01). plasma kshv dna levels were greater in aids-ks than i ...200312715309
association of high hiv-1 rna levels and homozygosity at hla class ii drb1 in adults coinfected with mycobacterium tuberculosis in harare, zimbabwe.hiv-1 mrna levels (virus load) were quantified for 191 pulmonary tuberculosis (tb) patients and 132 hiv-1 seropositive controls. human leukocyte antigen (hla) class i and ii genes were typed for 188 patients and 121 hiv-1 seropositive controls. the mean log virus load was higher among cases than hiv-1 seropositive controls (p < 0.0001). among the controls, mean log virus load was higher among males than females (p = 0.04). there was no association between virus load and homozygosity at hla class ...200212392855
health official emphasizes increase in malaria, aids, and tb incidence. international (zimbabwe).zimbabwe has recorded more than 255,000 cases of malaria since the rainy season began last november, 1996. almost 500 infected people have died of the disease. the death toll from malaria during the same period a year ago was 200; in all, over 2000 people died of malaria in 1996. the increase in disease incidence is attributed to the especially wet rainy season zimbabwe is experiencing this year. conditions are favorable for the disease-carrying mosquitoes to breed. timothy stamps, zimbabwe ...199712320873
study finds peer education is an effective prevention method.a comparative study conducted among factory workers in zimbabwe demonstrated that peer education has the potential to reduce the incidence of hiv. this study, sponsored by the university of zimbabwe in collaboration with stanford university (us), was the first evaluation of a health education strategy to use hiv infection as the measure of effectiveness. hiv incidence rates decreased significantly more in the factories where peer education was offered than in those without such a program. wor ...199812293302
relationship of human herpesvirus 8 peripheral blood virus load and kaposi's sarcoma clinical stage.to determine the relationship between human herpesvirus 8 (hhv-8 or kaposi's sarcoma-associated herpesvirus) peripheral blood virus load and kaposi's sarcoma (ks) clinical stage.200011061651
mortality in the first 2 years among infants born to human immunodeficiency virus-infected women in harare, zimbabwe.transmission of human immunodeficiency virus (hiv) and mortality was studied among infants of infected women in zimbabwe. of 367 infants born to hiv-infected women, 72 (19.6%) died compared with 20 (5.4%) of 372 infants of uninfected women (p < .01). infection by hiv dna polymerase chain reaction among infants who survived >7 days and died within 2 years could be assessed in 87% (58/67) of infants of infected women and 83% (5/6) of infants of uninfected women; transmission occurred in 40 of 58 i ...19989652429
cryptococcal meningitis in human immunodeficiency virus-infected patients in harare, zimbabwe.a prospective observational study was conducted over a 10-month period to determine the clinical and laboratory manifestations of cryptococcal meningitis in zimbabwe, a country where antifungal agents are not widely available. eighty-nine patients with cryptococcal meningitis (median age, 34 years; range, 11-63 years; 56 males) were identified from 406 patients for whom a clinical diagnosis of meningitis had been made. all patients tested were positive for antibody to human immunodeficiency viru ...19989502443
haematologic features of the human immunodeficiency virus (hiv) infection in black children in harare.forty six black zimbabwean children aged between three months and seven years who were admitted into parirenyatwa central hospital with serologically positive and symptomatic hiv infection were investigated for their haematologic profiles. tests done included full blood counts, manual white cell differential counts, coagulation screening tests and bone marrow aspiration in clinically indicated cases. anaemia was found in 84 pc, leucocytosis in 60 pc and thrombocytopaenia in 30 pc of the cases. i ...19947882412
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