| impact of crf01_ae-specific polymorphic mutations g335d and a371v in the connection subdomain of human immunodeficiency virus type 1 (hiv-1) reverse transcriptase (rt) on susceptibility to nucleoside rt inhibitors. | certain mutations in the connection subdomain and rnase h domain of reverse transcriptase (rt) of subtype b hiv-1 contribute to resistance to nucleoside reverse transcriptase inhibitors (nrtis). however, the impact of non-b subtype polymorphisms in this region on drug resistance remains unclear. in this study, we determined the frequencies of drug resistance mutations of the entire rt in patients with treatment failure from a cohort of circulating recombinant form (crf) 01_ae hiv-1-infected pati ... | 2010 | 20713171 |