| diagnostic sensitivity of polymerase chain reaction and southern blot hybridization for the detection of human papillomavirus dna in biopsy specimens from cervical lesions. | human papillomaviruses (hpvs) are associated with benign and malignant neoplasms of the cervix. one of the criteria for their etiologic role requires an assessment of whether virtually all or only a small fraction of lesions contain viral genomes. dna preparations from colposcopically directed punch biopsies of cervical lesions were analyzed by southern blot hybridization and the polymerase chain reaction (pcr) for the presence of hpv dna. the biopsy specimens represented different pathologic en ... | 1991 | 1850950 |
| genital human papillomavirus infection among women from major ethnic groups in singapore. | the close epidemiological relationships between specific genital human papillomavirus (hpv) types and neoplasia of the cervix uteri have been extensively documented worldwide, including singapore. cervical cancer incidence rates in singapore show variations between the major ethnic groups. to ascertain the corresponding hpv infection rates among the various races in singapore, we analysed the cervical smears of 225 women by filter in situ dna hybridization, and compared the data with a previous ... | 1990 | 1966000 |
| role of herpes simplex virus type-2 and human papilloma virus in penile cancers in singapore. | to detect the presence of herpes simplex virus type 2 (hsv-2) and human papilloma virus (hpv), common structural antigens in penile cancers, 20 squamous cell carcinomas were studied by immunohistochemical methods. all specimens were from singaporeans ranging in age from 44 to 69 years. none of the specimens contained hsv-2 and hpv common structural antigens. the reasons for the absence of hpv common antigen were discussed. the significance of the association of hpv with penile cancers is uncerta ... | 1987 | 2829697 |
| atypical condylomas of the cervix uteri in singapore women: a histopathological and immunohistochemical study. | subclinical flat cervical warts are commonly recognized by means of colposcopy. these warty lesions frequently contain cellular atypia of a varying degree showing all the features of cervical intraepithelial neoplasia (cin) together with the features of wart virus infection e.g. koilocytosis. human papillomavirus (hpv) antigens and dna have been found in these lesions which can be called atypical condylomas. the presence of such markers in lesions regarded as having neoplastic potential implicat ... | 1986 | 3021107 |
| singaporean women's knowledge of human papillomavirus (hpv) and attitudes toward hpv vaccination. | with a vaccination program currently planned to protect singaporean women from human papillomavirus, a need arises for assessing singaporean women's knowledge of human papillomavirus and attitudes toward human papillomavirus vaccination to identify barriers to a successful program and to help inform health education campaigns. a representative sample of 2,145 women aged between 18 and 49 years were randomly selected from households throughout singapore and interviewed with a similar questionnair ... | 2009 | 19753508 |
| assessing knowledge of human papillomavirus and collecting data on sexual behavior: computer assisted telephone versus face to face interviews. | education campaigns seeking to raise awareness of human papillomavirus (hpv) and promoting hpv vaccination depend on accurate surveys of public awareness and knowledge of hpv and related sexual behavior. however, the most recent population-based studies have relied largely on computer-assisted telephone interviews (cati) as opposed to face to face interviews (ftfi). it is currently unknown how these survey modes differ, and in particular whether they attract similar demographics and therefore le ... | 2009 | 19930668 |
| cost-effectiveness of different human papillomavirus vaccines in singapore. | human papillomavirus (hpv) vaccines are widely available and there have been studies exploring their potential clinical impact and cost-effectiveness. however, few studies have compared the cost-effectiveness among the 2 main vaccines available - a bivalent vaccine against hpv 16/18, and a quadrivalent vaccine against 6/11/16/18. we explore the cost-effectiveness of these two hpv vaccines in tropical singapore. | 2011 | 21453537 |
| the impact of cytology screening and hpv vaccination on the burden of cervical cancer. | aim: to evaluate the impact of different strategies of human papillomavirus (hpv) vaccination on the burden of cervical cancer in singapore. methods: the incidence of cervical cancer was calculated using a markov model with inputs based on singapore data for the prevalence of hpv infection, socioeconomic characteristics and screening prevalence. the evaluation was performed for 10 scenarios: no screening, current opportunistic cytology screening, ideal optimal screening, universal adolescent h ... | 2011 | 21585695 |