| stability of human immunodeficiency virus type 1 antibodies in whole blood dried on filter paper and stored under various tropical conditions in kinshasa, zaire. | the use of whole-blood spots on filter paper for the detection of antibody to human immunodeficiency virus type 1 (hiv-1) was evaluated during a 20-week period under a variety of storage environments simulating the harsh tropical field conditions in kinshasa, zaire. during the first 6 weeks of storage, all replicates of high- and low-titer hiv-1-positive reference samples remained positive by enzyme immunoassay and western blotting (immunoblotting), and all replicates of hiv-1-negative samples r ... | 1992 | 1583117 |
| seroconversion rate, mortality, and clinical manifestations associated with the receipt of a human immunodeficiency virus-infected blood transfusion in kinshasa, zaire. | to evaluate the consequences of receiving human immunodeficiency virus type 1 (hiv-1)-seropositive blood, 90 hiv-1-seronegative recipients of hiv-1-seropositive blood (case patients) and 90 hiv-1-seronegative recipients of hiv-1-seronegative blood, matched for age, sex, number of transfusions, diagnosis, and severity of illness (controls), were followed for 12 months after transfusion at mama yemo hospital in kinshasa, zaire. of case patients and controls, 72% were children transfused for anemia ... | 1991 | 1869835 |
| plasmodium falciparum malaria and perinatally acquired human immunodeficiency virus type 1 infection in kinshasa, zaire. a prospective, longitudinal cohort study of 587 children. | it is uncertain whether plasmodium falciparum malaria is more frequent or more severe in children with perinatally acquired human immunodeficiency virus type 1 (hiv-1) infection and whether p. falciparum infection accelerates the progression of hiv-related disease. | 1991 | 2052043 |
| field testing and comparative evaluation of rapid, visually read screening assays for antibody to human immunodeficiency virus. | five rapid, visually read assays for detection of antibody against human immunodeficiency virus (hiv) were evaluated on fresh serum samples from 4000 prospective blood donors at mama yemo hospital, kinshasa, zaïre. the sensitivity of the assays, based on 214 specimens positive by western blot, ranged from 84.6% to 99.1%. the specificity, based on 3664 samples negative by enzyme-linked immunosorbent assay (elisa) or western blot, ranged from 92.7% to 98.8%. three readers scored each test result i ... | 1989 | 2564112 |
| perinatal transmission of the human immunodeficiency virus type 1 to infants of seropositive women in zaire. | to examine perinatal transmission of the human immunodeficiency virus type 1 (hiv-1) in zaire, we screened 8108 women who gave birth at one of two kinshasa hospitals that serve populations of markedly different socioeconomic status. for up to one year, we followed the 475 infants of the 466 seropositive women (5.8 percent of those screened) and the 616 infants of 606 seronegative women matched for age, parity, and hospital. on the basis of clinical criteria, 85 of the seropositive women (18 perc ... | 1989 | 2786145 |
| surveillance for aids in a central african city. kinshasa, zaire. | surveillance for acquired immunodeficiency syndrome (aids) in kinshasa, zaire, was initiated in july 1984, using a modified version of the case definition developed by the centers for disease control. during the first eight months, 332 patients met all clinical and laboratory criteria; surveillance information was available for 295 (89%) of these patients. of the sera tested from these patients, 99% had antibodies to human t-cell lymphotropic virus type iii/lymphadenopathy-associated virus by bo ... | 1986 | 3012131 |
| [immunization against the human immunodeficiency virus in zaire]. | the first experimental immunization of human against the aids retrovirus hiv-1 was started in a series of hiv seronegative healthy volunteers in november 1986. priming used a vaccinia virus recombinant (v25) expressing gp 160 env determinants of htlv iii b at the surface of infected cells. this priming which induced a weak immune reaction was performed on hiv seronegative french and zaïrian individuals living in zaïre (kinshasa). these results prompted to boost the primary immune response. four ... | 1988 | 3221792 |
| absence of association between plasmodium falciparum malaria and human immunodeficiency virus infection in children in kinshasa, zaire. | the possible associations between plasmodium falciparum malaria and hiv (human immunodeficiency virus) seropositivity were investigated in 1986 at the mama yemo hospital in kinshasa, zaire. no significant difference was found in the hiv seropositivity rate of 164 children presenting with p. falciparum malaria (1.2%) and 169 healthy controls (0.6%). secondly, no association was found between p. falciparum slide positivity (51.6%) and hiv seropositivity (3.8%) among 1046 children presenting to the ... | 1987 | 3322600 |
| genetic diversity of human immunodeficiency virus type 1 strains in kinshasa, zaire. | the envelope (env) gene of human immunodeficiency virus type 1 (hiv-1) was amplified by polymerase chain reaction (pcr) from the peripheral blood mononuclear cells (pbmcs) of 14 hiv-1-infected women from kinshasa, zaire. amplified dna was directly sequenced with a primer specific for the hiv-1 env c2 region. the predicted amino acid sequences for the c2-v3 region for the 14 specimens are presented. the tetrapeptide sequence, gpgq, located at the crown of the v3 loop, is conserved in all specimen ... | 1993 | 8369166 |
| genital types of papillomavirus in children of women with hiv-1 infection in kinshasa, zaire. | increasing evidence indicates that infection with genital types of human papillomavirus (hpv) can occur prior to the onset of sexual activity, possibly by perinatal transmission. evidence is also accumulating that women infected with the human immunodeficiency virus (hiv) more frequently express hpv. we conducted this study to measure hpv prevalence in hiv-seropositive and -seronegative women in kinshasa, zaire and in their children. we collected cervico-vaginal lavage specimens from 80 mothers ... | 1993 | 8387461 |
| mycobacterium tuberculosis in household contacts of human immunodeficiency virus type 1-seropositive patients with active pulmonary tuberculosis in kinshasa, zaire. | rates of infection with mycobacterium tuberculosis were compared in kinshasa, zaire, in 521 household contacts of 74 human immunodeficiency virus type 1 (hiv-1)-seropositive index patients and in 692 household contacts of 95 hiv-1-seronegative [corrected] index patients with sputum smear-positive pulmonary tuberculosis: no difference was noted between contacts of hiv-1-seropositive and -seronegative patients. the increasing prevalence of m. tuberculosis infection with increasing age was similar ... | 1993 | 8515097 |
| neuropsychiatric hiv-1 infection study: in kenya and zaire cross-sectional phase i and ii. | the objective of the study was to determine the prevalence and natural history of human immunodeficiency virus type 1 (hiv-1) associated psychiatric, neuropsychological and neurological abnormalities. a total of 408 subjects were recruited in nairobi and kinshasa. the study consisted of a cross sectional phase and a longitudinal follow up. assessment was made by a data collection instrument including six modules. the intercentre and intracentre reliability in the use of the each module have been ... | 1995 | 8556777 |
| plasma cytokines, cytokine antagonists, and disease progression in african women infected with hiv-1. | to examine the relation of circulating cytokines and cytokine antagonists to the progression of human immunodeficiency virus type 1 (hiv-1) disease. | 1996 | 8633837 |
| short report: analysis of anti-malaria immune response during human immunodeficiency virus infection in adults in kinshasa, democratic republic of the congo. | co-infection of human immunodeficiency virus and malaria is not uncommon in people living in sub-saharan africa. since hiv infection results in immune deficiency, it may alter the ability of hiv patients to mount proper immune responses against malaria parasites. we measured specific malaria antibodies in 47 specimens from 25 couples from kinshasa, democratic republic of the congo (drc), according to their hiv status, and investigated probable interaction between malaria and hiv infection. plasm ... | 2003 | 12685648 |
| mechanism and history of evolution of symbiotic hiv strains into lethal pandemic strains: the key event may have been a 1927 trial of pamaquine in leopoldville (kinshasa), congo. | in previous papers, i have rejected both the zoonosis and the serial transfer hypotheses of the origin and evolution of the current lethal pandemic strains of hiv. the hypothesis that fits the critical observations is that all the human and nonhuman primate species in central africa (an area of hyper-endemic malaria) have shared (through inter-species transfers) a "primate t-cell retrovirus" (ptrv), which has adapted to each host species. this retrovirus is believed to assist primate t-cells att ... | 2007 | 17368749 |