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comparison of epstein-barr virus genotypes and clinicohistopathological features of nasopharyngeal carcinoma between guilin, china and fukuoka, japan.epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc) is endemic to guilin, china, but not fukuoka, japan. to examine whether the npc in these two cities are distinct in their association with ebv, we analyzed the histology and ebv genotypes in 163 npc from guilin, 52 npc from fukuoka and non-cancerous control nasopharyngeal tissues (n=22 each) by in situ hybridization and pcr. the proportion of ebv-positive npc from guilin (95%) was higher than that of fukuoka (55%, p<0.001), and h ...200818497945
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