| complex transmission dynamics of clonally related virulent mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men. | limited data suggest that measures to reduce tuberculosis transmission should be based on locations rather than on personal contacts. molecular epidemiologic methods (analysis of is6110 patterns, spoligotypes, variable numbers of tandem dna repeats, and automated dna sequence data) identified a cohort of 48 persons who were infected with progeny of the same mycobacterium tuberculosis strain. epidemiologic investigation documented that a large proportion of the patients were gay white human immun ... | 1999 | 10479154 |
| number of negative acid-fast smears needed to adequately assess infectivity of patients with pulmonary tuberculosis. | to investigate the relationship between the number of negative acid-fast bacilli (afb) smear results and infectivity of pulmonary tuberculosis (tb). | 2005 | 16002923 |
| progress in understanding the human immune responses to mycobacterium tuberculosis. | development of an effective vaccine against tuberculosis hinges on an improved understanding of the human immune response to mycobacterium tuberculosis. work in this area at the university of texas health science center at tyler has led to advances in four areas: (1) natural killer cells contribute to innate immunity by lysing m. tuberculosis-infected mononuclear phagocytes, and to adaptive immunity by enhancing the cd8+ t-cell effector function and inhibiting expansion of t regulatory cells; (2 ... | 2009 | 20006306 |
| alleles of the nramp1 gene are risk factors for pediatric tuberculosis disease. | relatively little is known about the human genetics of susceptibility to common diseases caused by bacterial pathogens. tuberculosis, caused by mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. so far, genetic studies of tuberculosis susceptibility have largely been focused on adult patients despite the fact that tuberculosis is highly prevalent among children. to study the host genetic component of pediatric tuberculosis susceptibility, we enrolled 184 ethnicall ... | 2005 | 16103355 |